Pay in installments of $49.54 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 3 - Aug 8
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Microglial Aging: Basic, Translational and Clinical AdvancesMicroglial Aging: Basic, Translational, and Clinical Advances explores groundbreaking research on microglial function in the context of aging. This comprehensive resource delves into the physiological roles of microglia, the effects of aging on their structure and activity, and their significance in age related neurodegenerative diseases. With insights from basic, translational, and clinical studies, it provides a thorough understanding of microglial
Microglial Aging: Basic, Translational, and Clinical Advances explores groundbreaking research on microglial function in the context of aging. This comprehensive resource delves into the physiological roles of microglia, the effects of aging on their structure and activity, and their significance in age-related neurodegenerative diseases. With insights from basic, translational, and clinical studies, it provides a thorough understanding of microglial health and its impact on aging. The book discusses how lifestyle choices can enhance microglial functions and prevent neurodegenerative diseases. It covers both pharmacological and non-pharmacological approaches, such as the ketogenic diet, cannabinoids, psychedelics, and non-invasive vagal nerve stimulation.This text is invaluable for researchers and clinicians focused on improving the quality of life for an aging population.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy
4.3 ★★★★★
Based on 17 reviews
Sort
Product Reviews
★★★★★ 5
Best toy/treat! (Use oil on inner screw to open)
Size: Large, Color: Green
My dogs love these! This gives them a dedicated 20-40min of dog joy. They often get up halfway thru and switch but whatever makes them happy. They do get STUCK! And can be impossible to open. I now use a dot of olive oil on each level of the screw and then twist it in and out a couple times to distribute the lube so its possible to open when they are done. I find it very important to collect them immediately when they are done and open back up for cleaning. Do not let them dry as it will be very difficult to open.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 11, 2026
★★★★★ 5
These are must haves for dog owners!
Size: Large, Color: Pink
These things have saved my sanity! I have two dogs and we use these at least two to three times per week. They are high quality and last thru heavy chewers. We spread peanut butter inside for a quick treat when clipping nails, or make our own mix of Greek yogurt, dry oatmeal, diced carrots, a little pumpkin, and a bit of diced apple, mix it up and freeze it in the Pupsicle mold. That way we have a bunch ready to go and aren’t buying expensive refills. The colors are adorable, the pupsicle is durable, and the dogs LOVE them. FYI - it’s a good idea to use a little olive or avalado oil on the threads when closing them up - it makes life so much easier when screwing then on and off. We throw ours into the dishwasher.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 6, 2026
★★★★★ 5
Like unto the Holy Grail of food toys. [I recommend buying the separate treat mold, too.]
Size: Large, Color: Green
So far, I have no complaints. I can see that this toy might not work well for some combinations of dogs and people, but for my two current dogs (blue heeler and small terrier), this thing, plus the treat mold, is GREAT!
I love that the dogs get it more or less fully emptied, and it is washable. I love that I can pre-prepare a whole bunch of frozen fillings by using the treat mold (sold separately).
Yes, I agree that this is a very expensive item, especially if you buy the treat mold along with the toy. I bought two toys at a very reduced price on Prime day, also bought the treat mold at full price, and consider the combined purchase a great value at this cost. The current price (for the toy) is comparable to the cost of an extra-large Toppl, and I've seen it at a price similar to the current cost of a large Toppl. I checked the current price of the XXL "extreme" Kong I needed to use for one dog, and the current price on a different web site is almost the same as the Woof Pupsicle.
To answer questions and issues I've seen mentioned...
* My terrier weighs 16 pounds and uses the large toy with no problem. Possibly it is minimally less thoroughly cleaned out, but I'm not positive about that. My only warning would be that you ought to keep track of calories and/or what you put in it because you could potentially give a small dog way too many empty calories from "junk food."
* The toy is still usable without the treat mold. Just fill up the solid half of the toy and stick it in the freezer overnight, same as you would do with a Kong, except it takes up less space.
* Do introduce it properly, by initially giving it with NON-frozen and sticky food in it. An even more slow, careful, step-wise introduction may be necessary if your dog is a destructo-dog.
* The terrier takes about 20 minutes to empty it of frozen canned dog food. That's non-trivial, and I'm not sure why people are complaining. The heeler takes less time (maybe 15 minutes?), but it's still an amount of time that is helpful for me, and this licking activity seems to be especially calming for her (as compared to using the food puzzle toys with kibble).
* It initially was extremely difficult to open and close the thing. I was best able to do it with a "light" touch, not pulling and making sure not to press the two surfaces together. After not very long, it became much easier. I didn't need to use oil. If you have trouble getting it closed, it became a lot easier after the solid part was frozen (while the vented part stayed at room temperature).
* I agree with others that a larger version might be nice, but a larger version might make dogs more likely to destroy the toy in place of emptying it by focused licking.
* I'm not sure that any of these toys are truly indestructible. People are mentioning Kongs. Well, my Kongs have required periodic replacement. They have tooth marks and eventually get "modified" to where pieces might get torn off and consumed. For one dog, I had to upgrade to the XXL-size Extreme (black) version, and she also put tooth marks in that.
I own a fortune's worth of Kongs, Toppls, and a couple similar food toys, and they all have their issues. They have holes in them that allow liquid to immediately come out (before freezing occurs). They are bulky and use up a lot of space in the freezer, and the unusual shapes make them non-stackable. For me, Kong toys are time-consuming to fill and difficult to clean. My dogs couldn't get the very end cleaned out without throwing the Kong around (making a big mess), and even then it wasn't fully clean. Some did end up with mold in that part of them. [It looks like new inventions, like plugs (or something like that), may solve some of the problems; I didn't have those.]
I mention the other toys only to say that this unique brilliant toy has seeming solved all those problems, and my dogs truly LOVE this toy as well. Be assured, I will update this review if anything changes.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 24, 2023
★★★★★ 4
Perfect for Our Nervous Rescue Dog
Size: Large, Color: Green
First Impressions
I bought the Pupsicle for our new rescue dog who was very nervous whenever we had to leave the house. Right out of the box it felt sturdy and well-made, and I liked that it wasn’t just another cheap chew toy.
⸻
Setup & Ease of Use
I went with the premade treat inserts to start, which made it super simple — just pop one in and hand it over. It’s also dishwasher-safe, which is a huge win for me since I don’t want to deal with scrubbing peanut butter out of toys.
⸻
Performance in Real Life
She loves it. The Pupsicle has kept her occupied and calm, which has really helped her acclimate to her new home. Instead of pacing or whining when we leave, she settles down with this toy and stays busy.
⸻
Pros & Cons
Pros:
• Helps reduce anxiety for nervous dogs
• Very durable and solid
• Easy to clean (dishwasher safe)
• Premade inserts make it effortless
Cons:
• On the heavier side, so probably best for medium+ dogs
• Inserts are convenient but add a little extra cost
⸻
Who It’s For
Perfect for new dog owners, rescues, or anyone with a dog who needs a healthy distraction when left alone.
⸻
Final Verdict
The Pupsicle has made a noticeable difference for our rescue pup. It’s durable, easy to use, and has genuinely helped her feel more at ease in her new environment. Highly recommend.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 24, 2025
★★★★★ 3
Dogs love it, hard to open and close
Size: Large, Color: Pink, Size: Large, Color: Pink
My dogs love this toy. It keeps them entertained a long time. Great calming toy for when you leave the house. Only issues is it is very hard to open and close. One of mine I had three people try to open and after fighting with it for about an hour I finally got it opened. Got 2, one a blue and pink one for each of my dogs. The blue is easier than the pink but still hard to do. Just not as bad. Can't close the pink all the way because it is so hard to close. The dog that uses it has trouble getting the stuff out of it. But it doesn't stop her from trying for hours to do so. Does get some teeth marks on it as well if they are aggressive chewer. Tried multiple eatable lubricating substances to try to make it easier but so far nothing fully worked. Aloe Vera has worked the best so far, but not great.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 17, 2026
recommand products
Benu Supreme Fountain Pen - Symphony
111.00
SANDRO collarless felted cropped jacket
1749.50
Blueprint Framing Plan - Plummer Tobacco Barn, 2485 Chaneyville Road, Chaneyville, Calvert County, MD
24.99
Mugler cut-out detailing blazer
1749.50
Maximum Human Performance, Anadrox Pump & Burn Wild Cherry, 30 Servings
25.99