Polyethyleneimine (PEI) modified Au Nanoparticles

Polyethyleneimine (PEI) modified Au NanoparticlesProduct Name Polyethyleneimine (PEI) modified Au nanomaterials Product Overview PEI modified gold nanoparticles are modified with PEI on top of PEG modified gold nanoparticles, and this operation makes the nanoparticles positively charged. Technical Parameter Concentration: 0. 05mg ml Solvent: water Remarks: Concentration is obtained according to the feeding ratio, actual consumption will be lower than 0. 05mg ml. Product Features Efficient gene

Product Name

Polyethyleneimine (PEI) modified  Au nanomaterials

Product Overview

PEI-modified gold nanoparticles are modified with PEI on top of PEG-modified gold nanoparticles, and this operation makes the nanoparticles positively charged.

Technical Parameter 

Concentration: 0.05mg/ml

Solvent: water

Remarks: Concentration is obtained according to the feeding ratio, actual consumption will be lower than 0.05mg/ml.

Product Features

Efficient gene delivery: PEI-modified gold nanoparticles can be used as efficient gene carriers, forming complexes with DNA through electrostatic adsorption to enhance the efficiency of gene delivery. 

Excellent biocompatibility: PEI is a cationic polymer that interacts with cell membranes and promotes the binding of nanoparticles to cells, enhancing their stability and biocompatibility in organisms. 

Enhanced Optical Properties: Gold nanoparticles inherently have a unique surface plasmon resonance (SPR) effect, and PEI modification can further modulate their optical properties, such as absorption and scattering characteristics, giving them potential applications in optical imaging and sensing.

Multimodal imaging capability: PEI-modified gold nanoparticles can be used in a variety of imaging techniques, such as magnetic resonance imaging (MRI), photoacoustic imaging and CT imaging, providing multimodal imaging capability.

Application Fields

Gene and siRNA delivery: PEI-modified gold nanoparticles can be used as gene and siRNA delivery carriers. It has been shown that PEI-modified gold nanoparticles can bind siRNA via covalent bonding, form complexes, and induce degradation of target mRNAs via the RNA interference (RNAi) mechanism. This approach shows high efficiency and low cytotoxicity in gene silencing.

Photothermal therapy: PEI-modified gold nanoparticles have shown excellent performance in photothermal therapy. The plasmon resonance effect on the surface of gold nanoparticles allows them to efficiently convert light energy into heat under near-infrared light irradiation, generating localised high temperatures that can kill tumour cells.PEI modification further enhances the stability and biocompatibility of the nanoparticles. 

Targeted drug delivery: PEI-modified gold nanoparticles can be surface-modified with targeted ligands (e.g., folic acid, aptamers, hyaluronic acid, glutathione, peptides, and antibodies) for targeted drug delivery. This targeting significantly increases drug concentration in cancer cells and reduces toxicity to normal cells. 

Radiosensitisation: PEI-modified gold nanoparticles can be used as radiosensitisers in radiotherapy. Gold nanoparticles can enhance the radiation effect of X-rays and increase the sensitivity of tumour cells to radiation, thus enhancing the effect of radiotherapy.

Related Information

Storage: Sealed, refrigerated at 4¡ãCand protected from light.

Expiry date: 6 months

Please e-mail for the detailed characterization data.

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