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Description
TUBA1B Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen TUBA1B Synonyms Tubulin alpha 1B chain; Alpha tubulin ubiquitous; Tubulin K alpha 1; Tubulin alpha ubiquitous chain Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton Accession P68363 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample HEK 293, HeLa, MCF7, NIH 3T3, PC 12, COS 7 Purification Immunogen Affinity Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | TUBA1B |
| Synonyms | Tubulin alpha-1B chain; Alpha-tubulin ubiquitous; Tubulin K-alpha-1; Tubulin alpha-ubiquitous chain |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton |
| Accession | P68363 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HEK-293, HeLa, MCF7, NIH/3T3, PC-12, COS-7 |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms |
Background
TUBA1B (tubulin alpha-1B chain) is a ubiquitously expressed cytoskeletal protein that polymerizes with beta-tubulin to form microtubules, thereby orchestrating mitotic spindle assembly, intracellular transport, cell shape and motility; its over-expression is frequently observed in multiple cancers where it drives proliferation, migration and invasion, correlates with advanced stage and poor survival, modulates innate and adaptive immune signaling, and predicts response to immune-checkpoint inhibition, making it an emerging prognostic biomarker and potential therapeutic target.
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