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Description
Human TrkB , His tagProduct Specification Species Human Synonyms GP145 TrkB (Trk B), Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin related kinase B, NTRK2 Accession Q16620 Amino Acid Sequence Protein sequence(Q16620, Trp230 His430, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | GP145-TrkB (Trk-B), Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B, NTRK2 |
| Accession | Q16620 |
| Amino Acid Sequence | Protein sequence(Q16620, Trp230-His430, with C-10*His) WDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHGGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | Theoretical:24kDa Actual: 35-45kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
Tropomyosin receptor kinase B is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations. The neurotrophins that activate TrkB are: BDNF (Brain Derived Neurotrophic Factor), neurotrophin-4 (NT-4), and neurotrophin-3 (NT-3). Although originally identified as an oncogenic fusion in 1982, only recently has there been a renewed interest in the Trk family as it relates to its role in human cancers because of the identification of NTRK1 (TrkA), NTRK2 (TrkB) and NTRK3 (TrkC) gene fusions and other oncogenic alterations in a number of tumor types. A number of Trk inhibitors are in clinical trials and have shown early promise in shrinking human tumors. TrkB and its ligand BDNF have been associated to both normal brain function and in the pathology and progression of Alzheimer’s disease (AD) and other neurodegenerative disorders.
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Exchange/Return Notes
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4.7 ★★★★★
Based on 17 reviews
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Product Reviews
★★★★★ 4
Nice quality
Color: Gray/Silver, Size: Pack of 50
Best price for the quantity
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Reviewed in the United States on May 30, 2026
★★★★★ 5
Space-Saving, Stylish, and Surprisingly Strong Closet Upgrade
Color: Black, Size: Pack of 100
I’ve been using these Amazon Basics slim velvet hangers, and they completely changed how organized my closet feels. The biggest difference is how much space they save. Because they’re so thin compared to regular plastic hangers, I was able to fit a lot more clothes in the same closet without it feeling crowded.
The velvet coating is also a great feature. Clothes actually stay in place and don’t slip off, even lighter fabrics like tank tops or blouses. That alone makes getting dressed in the morning easier because I’m not constantly picking things up off the floor.
They feel sturdy too. Even though they are slim, they hold heavier items like jackets and sweaters without bending or breaking. The shape helps keep clothes looking neat and prevents those annoying shoulder bumps that some hangers cause.
I also like the clean black and silver look, it gives the closet a more uniform and organized appearance, which makes everything feel more put together.
Overall, these hangers are a simple but very effective upgrade for any closet. They save space, keep clothes in place, and make everything look more organized without much effort.
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Reviewed in the United States on April 21, 2026
★★★★★ 5
Looks more organized than bulky plastic hangers and multiple colors
Color: Black/Rose Gold, Size: Pack of 100
Love these hangers! The cloth helps from shirts slipping off and holds them in place! Stylish and thin so doesn’t take up all space on rack either! I’ve changed all our hangers over to these!
They are very durable and there’s no assembly obviously. I’ve had one break, but that was with a pair of jeans hanging on it and I yanked the jeans instead of pulling the hanger off and taking the jeans off the hanger so I would say they’re pretty durable. There’s a lot of overweight people here and so the jeans and certain items are pretty heavy. I’m able to hang my husband uniforms in sets on them pants and then the shirt over top. Love these hangers.
However, customer service is unreachable and when order you may be waiting for months to receive them!
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Reviewed in the United States on April 2, 2026
★★★★★ 5
Good product
Color: Black, Size: Pack of 50
I love this product. Actually is the second time that I buy from this company. It is very sturdy and has a good grip and also is beautiful. I recommend it.
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Reviewed in the United States on May 27, 2026
★★★★★ 5
Overall, they’re a great way to display memories and decorate any space
Color: Black, Size: 11x17
Love these frames, They are really good quality and feel sturdy, not cheap at all. They were very easy to set up and insert my pictures, which I really appreciate. The size is perfect for posters or photos, and they make everything look much more professional and elegant on the wall. I also like how they fit well with any home decor style
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Reviewed in the United States on April 21, 2026