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Description
Glycoprotein/GP His Tag Protein, Ebola Virus-Q7T9D9Product Specification Synonyms Glycoprotein,GP,Ebola virus EBOV (subtype Sudan,strain Gulu) GP Accession Q7T9D9 Amino Acid Sequence Target (Met1 Asn637) with His Tag at the C terminal Expression System HEK293 Molecular Weight 17 23 & 95 130 kDa(Reducing) Purity 95% by SDS PAGE &90% by SEC HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS PH7. 4 5% trehalose Stability & Storage 12
Product Specification
| Synonyms | Glycoprotein,GP,Ebola virus EBOV (subtype Sudan,strain Gulu) GP |
| Accession | Q7T9D9 |
| Amino Acid Sequence | Target (Met1-Asn637) with His Tag at the C-terminal |
| Expression System | HEK293 |
| Molecular Weight | 17-23 & 95-130 kDa(Reducing) |
| Purity | ＞95% by SDS-PAGE &＞90% by SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS PH7.4 5% trehalose |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Sanchez A, Lukwiya M, Bausch D, Mahanty S, Sanchez AJ, Wagoner KD, Rollin PE. Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: cellular responses, virus load, and nitric oxide levels. J Virol. 2004 Oct;78(19):10370-7. |
Background
The fourth gene of the EBOV genome encodes a 16-kDa envelope-attached glycoprotein (GP) and an 11-kDa secreted glycoprotein (sGP), both sharing a 295-residue N-terminus but differing in C-terminal sequences. GP, a class I fusion protein forming trimers on the viral surface, is critical for virus entry and attachment. Mature GP is a disulfide-linked heterodimer of GP1 and GP2, produced by furin cleavage of the precursor (pre-GP) during assembly. GP1 contains a mucin domain and receptor-binding domain (RBD), while GP2 includes a fusion peptide, heptad-repeat region, transmembrane domain, and cytoplasmic tail. The RBD mediates interaction with cellular receptors such as DC-SIGN, TIM-1, NPC1, and others, with TIM-1 and NPC1 essential for entry. The mucin domain enhances attachment to hMGL and shields neutralization epitopes, aiding immune evasion. During membrane fusion, GP2 undergoes conformational changes that insert the fusion loop into the host membrane, facilitating release of the viral nucleocapsid into the cytoplasm.
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