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Description
RRM1 Recombinant Rabbit mAb (SDT-R152)Product Specification Host Rabbit Antigen RRM1 Synonyms Ribonucleoside diphosphate reductase large subunit, Ribonucleoside diphosphate reductase subunit M1, Ribonucleotide reductase large subunit Immunogen N A Location Cytoplasm Accession P23921 Clone Number SDT R152 Antibody Type Recombinant mAb Application IHC P, ICC, ICFCM Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0.
Product Specification
| Host | Rabbit |
| Antigen | RRM1 |
| Synonyms | Ribonucleoside-diphosphate reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1, Ribonucleotide reductase large subunit |
| Immunogen | N/A |
| Location | Cytoplasm |
| Accession | P23921 |
| Clone Number | SDT-R152 |
| Antibody Type | Recombinant mAb |
| Application | IHC-P, ICC, ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:100 | |
| ICC | 1:500 | |
| ICFCM | 1:50 |
Background
The large subunit of human ribonucleotide reductase, RRM1, is involved in the regulation of cell proliferation, cell migration, tumour and metastasis development, and the synthesis of deoxyribonucleotides for DNA synthesis. It is also a cellular target for the chemotherapeutic agent, gemcitabine. RRM1 has been studied in a large number of patients with different types of cancer, such as non-small-cell lung cancer, pancreatic cancer, breast cancer, and biliary tract cancer, to establish its prognostic or predictive value when patients were treated with gemcitabine, and mRNA expression and genetic variants as determined by genotyping have in some cases been associated with clinical outcome of patients with cancer [PMID: 21163702].
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