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Description
CD96/TACTILE (C110S) His Tag Protein, HumanProduct Specification Species Human Synonyms TACTILE Accession P40200 2 Amino Acid Sequence Val22 Met503(C110S), with C terminal His Expression System HEK293 Molecular Weight 90 120kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation.
Product Specification
| Species | Human |
| Synonyms | TACTILE |
| Accession | P40200-2 |
| Amino Acid Sequence | Val22-Met503(C110S), with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 90-120kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Eur J Immunol . 2020 Jun;50(6):891-902.Epub 2020 Feb 20. |
Background
Human CD96, also known as haptic (late expression of increased T cell activation), is a 160 kDa type I transmembrane glycoprotein of the Ig superfamily, with CD226, CD96 and TIGIT sharing the ligand CD155, which plays an important role in the regulation of NK cell function. Mature human CD96 contains an extracellular region of 498 aa, including three Igg-like domains. The two n-terminal domains are V-type structures, and the distal domains are C-type structures. Studies have shown that NK cells recognize the poliovirus receptor (PVR), a member of the connectin and connectin-like protein family that mediates cell-cell adhesion and cell migration in the presence of the CD96 receptor.
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