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Description
Armenian hamster Anti-Mouse CD272 Antibody (S-R709)Product Specification Host Armenian hamster Antigen CD272 Synonyms B and T lymphocyte attenuator; B and T lymphocyte associated protein; Btla Location Cell membrane Accession Q7TSA3 Clone Number S R709 Antibody Type Recombinant mAb Isotype IgG Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability &
Product Specification
| Host | Armenian hamster |
| Antigen | CD272 |
| Synonyms | B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; Btla |
| Location | Cell membrane |
| Accession | Q7TSA3 |
| Clone Number | S-R709 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Ms |
Background
CD272, also known as BTLA (B- and T-lymphocyte attenuator), is an inhibitory receptor belonging to the CD28 immunoglobulin superfamily. It is a type I transmembrane glycoprotein expressed by most lymphocytes, including T and B cells. BTLA shares structural and functional similarities with CTLA-4 and PD-1, but it is distinct in that it interacts with the tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpesvirus entry mediator (HVEM), rather than just the B7 family of cell surface receptors. This interaction plays a crucial role in negatively regulating T-cell immune responses. BTLA is involved in maintaining lymphocyte homeostasis and preventing excessive immune activation. It has potential implications in various diseases, including cancer and autoimmune disorders, where immune regulation is critical.
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