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Description
GSK3A/B Recombinant Rabbit mAb (S-2659-135)Product Specification Host Rabbit Antigen Phospho GSK3a (Ser21 9) Synonyms Glycogen synthase kinase 3 alpha; GSK 3 alpha; Serine threonine protein kinase GSK3A; GSK3A Immunogen Recombinant Protein Location Cytoplasm, Nucleus, Mitochondrion, Synapse Accession P49840 Clone Number S 2659 135 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt, Mk Positive Sample HeLa, HEK 293, HepG2, A431, MCF7, Neuro 2a, NIH 3T3, PC 12, C6,
Product Specification
| Host | Rabbit |
| Antigen | Phospho-GSK3a/β (Ser21/9) |
| Synonyms | Glycogen synthase kinase-3 alpha; GSK-3 alpha; Serine/threonine-protein kinase GSK3A; GSK3A |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus, Mitochondrion, Synapse |
| Accession | P49840 |
| Clone Number | S-2659-135 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HeLa, HEK-293, HepG2, A431, MCF7, Neuro-2a, NIH/3T3, PC-12, C6, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
Background
Phospho-GSK3α/β (Ser21/9) is the phosphorylated, inactive form of glycogen synthase kinase-3 alpha and beta isoforms, generated when AKT, MAPK and other kinases add a phosphate to Ser21 of GSK3α or the homologous Ser9 of GSK3β, thereby creating an N-terminal pseudo-substrate that folds back into the catalytic pocket to block substrate access and halt the enzyme’s constitutive suppression of glycogen synthesis, β-catenin signaling, NF-κB activity and other metabolic/transcriptional programs; detection of this phospho-epitope therefore serves as a widely used biomarker for PI3K–AKT–mTOR pathway activation and for cellular responses to insulin, growth factors, oxidative stress and Wnt stimuli.
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