SKU: 13306086084

GluN3B Recombinant Rabbit mAb (S-2320-3)

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Description

GluN3B Recombinant Rabbit mAb (S-2320-3)Product Specification Host Rabbit Antigen GluN3B Synonyms Glutamate receptor ionotropic, NMDA 3B; GRIN3B Immunogen Recombinant Protein Location Cell membrane Accession O60391 Clone Number S 2320 3 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms Positive Sample CHO transfected with GluN3B Myc His fusion protein Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage

Product Specification


Host Rabbit
Antigen GluN3B
Synonyms Glutamate receptor ionotropic, NMDA 3B; GRIN3B
Immunogen Recombinant Protein
Location Cell membrane
Accession O60391
Clone Number S-2320-3
Antibody Type Recombinant mAb
Isotype IgG
Application WB, ICC
Reactivity Hu, Ms
Positive Sample CHO transfected with GluN3B-Myc-His fusion protein
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:500-1:1000 Ms
ICC 1:500 Ms

Background

GluN3B, encoded by the GRIN3B gene, is a unique and atypical subunit of the N-methyl-D-aspartate receptor (NMDAR) that fundamentally alters the receptor's functional properties when co-assembled with obligatory GluN1 subunits and conventional GluN2 subunits. Unlike other NMDAR subunits, GluN3B contains a distinct ligand-binding domain that renders the resulting heterotrimeric or heterotetrameric receptors insensitive to the co-agonist glycine and significantly reduces their calcium permeability and single-channel conductance, effectively acting as a dominant-negative modulator that dampens excitatory synaptic transmission. Primarily expressed in specific brain regions such as the thalamus, striatum, and during early postnatal development in the cortex, GluN3B plays a critical role in refining neural circuits by limiting excessive NMDAR activity, thereby influencing processes like synaptic plasticity, motor coordination, and sensory gating; furthermore, dysregulation or mutations in GRIN3B have been implicated in various neurological disorders, including schizophrenia, Huntington's disease, and rare forms of epilepsy, highlighting its importance as a potential therapeutic target for modulating glutamatergic signaling without completely abolishing NMDAR function.

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SKU: 13306086084

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★★★★★ 5
Best sock I've ever had!
Size: Large, Color: White, Size: Large, Color: White
I have these same socks in white and gray, oh, and a couple of colors, and they are my favorite socks. They're the most comfortable, best-fitting socks I've ever ordered.
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Colleen R.
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★★★★★ 5
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