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Description
Desmoglein 3 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen Desmoglein 3 Synonyms Desmoglein 3; 130 kDa pemphigus vulgaris antigen (PVA); Cadherin family member 6; CDHF6; DSG3 Immunogen Synthetic Peptide Location Cytoplasm, Cell membrane Accession P32926 Antibody Type Polyclonal antibody Isotype IgG Application WB Reactivity Hu Positive Sample A431, HaCaT Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | Desmoglein 3 |
| Synonyms | Desmoglein-3; 130 kDa pemphigus vulgaris antigen (PVA); Cadherin family member 6; CDHF6; DSG3 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cell membrane |
| Accession | P32926 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | A431, HaCaT |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
Desmoglein-3 (Dsg3) is a calcium-dependent transmembrane glycoprotein and a key component of desmosomes, specialized cell-cell adhesion structures primarily found in stratified squamous epithelia such as the skin and oral mucosa; it functions to maintain tissue integrity by anchoring intermediate filaments of the cytoskeleton to sites of intercellular contact, and beyond its structural role, Dsg3 actively regulates epithelial homeostasis by suppressing p53-mediated stress responses, thereby acting as an anti-stress protein that protects keratinocytes from apoptosis induced by UVB, mechanical stress, or genotoxic agents, while also promoting cancer cell migration and invasion through activation of the AP-1 transcription factor and PKC-dependent phosphorylation of ezrin, and its autoimmune targeting by autoantibodies results in the loss of adhesion and blister formation characteristic of pemphigus vulgaris, making Dsg3 a central player in both physiological epithelial cohesion and pathological processes including cancer metastasis and autoimmune blistering diseases.
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