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Description
Alexa Fluor® 700 Mouse Anti-Human CD73 Antibody (S-715-115)Product Specification Host Mouse Antigen CD73 Synonyms 5' nucleotidase; 5' NT; 5' deoxynucleotidase; Ecto 5' nucleotidase; IMP specific 5' nucleotidase; Thymidylate 5' phosphatase; NT5; NTE; NT5E Immunogen Recombinant Protein Location Cell membrane Accession P21589 Clone Number S 715 115 Antibody Type Mouse mAb Isotype IgG2b,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation Alexa
Product Specification
| Host | Mouse |
| Antigen | CD73 |
| Synonyms | 5'-nucleotidase; 5'-NT; 5'-deoxynucleotidase; Ecto-5'-nucleotidase; IMP-specific 5'-nucleotidase; Thymidylate 5'-phosphatase; NT5; NTE; NT5E |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P21589 |
| Clone Number | S-715-115 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 700 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD73, also known as ecto-5'-nucleotidase (encoded by NT5E), is a glycosylphosphatidylinositol (GPI)-anchored cell-surface enzyme that catalyzes the final step of extracellular ATP degradation, converting AMP to immunosuppressive adenosine, thereby orchestrating tumor immune evasion, promoting angiogenesis and metastasis, and shaping an anti-inflammatory microenvironment by dampening CD8⁺ T-cell cytotoxicity and enhancing Treg or myeloid suppressive functions across multiple solid cancers.
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Exchange/Return Notes
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