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Description
PACAP Recombinant Rabbit mAb (SDT-2454-48)Product Specification Host Rabbit Antigen PACAP Synonyms Pituitary adenylate cyclase activating polypeptide; Pituitary adenylate cyclase activating polypeptide 27 (PACAP 27; PACAP27); Pituitary adenylate cyclase activating polypeptide 38 (PACAP 38; PACAP38) Immunogen Synthetic Peptide Accession P18509 Clone Number SDT 2454 48 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA Reactivity Hu Cross Reactivity It reacts with both PACAP
Product Specification
| Host | Rabbit |
| Antigen | PACAP |
| Synonyms | Pituitary adenylate cyclase-activating polypeptide; Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27; PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38; PACAP38) |
| Immunogen | Synthetic Peptide |
| Accession | P18509 |
| Clone Number | SDT-2454-48 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | It reacts with both PACAP-27 and PACAP-38 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide) is a neuropeptide widely distributed in the nervous and endocrine systems. It functions as a potent neurotransmitter, neuromodulator, and vasodilator, playing crucial roles in stress response, metabolism, and cerebral blood flow regulation. Detection of PACAP holds significant clinical and research value. It is primarily measured in plasma or cerebrospinal fluid using immunoassays like ELISA. Its major significance lies in its strong association with primary headache disorders, particularly migraine. PACAP levels can serve as a potential biomarker for migraine pathophysiology, aiding in understanding attack mechanisms and evaluating treatment efficacy, especially for emerging PACAP-targeted therapies. Furthermore, its detection supports research into its roles in other conditions like inflammation, psychiatric disorders, and metabolic diseases.
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