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Description
Mouse Anti-Human CD337 (NKp30) Antibody (S-3172)Product Specification Host Mouse Antigen CD337 (NKp30) Synonyms Natural cytotoxicity triggering receptor 3; Activating natural killer receptor p30; Natural killer cell p30 related protein (NK p30; NKp30); 1C7; LY117; NCR3 Location Cell membrane Accession O14931 Clone Number S 3172 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein G Concentration 2 mg ml Conjugation Unconjugated
Product Specification
| Host | Mouse |
| Antigen | CD337 (NKp30) |
| Synonyms | Natural cytotoxicity triggering receptor 3; Activating natural killer receptor p30; Natural killer cell p30-related protein (NK-p30; NKp30); 1C7; LY117; NCR3 |
| Location | Cell membrane |
| Accession | O14931 |
| Clone Number | S-3172 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD337, also known as NKp30 or NCR3, is a 30 kDa type-I transmembrane glycoprotein expressed almost exclusively by resting and activated natural killer (NK) cells; it contains a single V-type immunoglobulin-like extracellular domain, a positively charged transmembrane arginine that couples to the ITAM-bearing adaptors CD3ζ and FcεRγ, and exists as six alternatively spliced isoforms that differ in signalling potency. Acting as a major activating receptor within the natural cytotoxicity receptor (NCR) family, NKp30 triggers NK-cell cytotoxicity and cytokine release against tumour, virus-infected or immature dendritic cells that have down-regulated MHC-I, by recognising ligands such as the tumour-derived nuclear chaperone B7-H6 and BAT3; however, soluble forms of these ligands can down-regulate NKp30 and foster immune evasion.
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