SKU: 14043899687

Human LCK, His tag

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Description

Human LCK, His tagProduct Specification Species Human Accession P06239 Amino Acid Sequence Protein sequence(P06239, Asn64 Thr226, with C 10*His) NLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTGGGGSHHHHHHHHHH Expression System HEK293 Molecular Weight Theoretical: 20. 1kDa Actual: 24 30kDa Purity >90% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated

Product Specification


Species Human
Accession P06239
Amino Acid Sequence

Protein sequence(P06239, Asn64-Thr226, with C-10*His)
NLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTGGGGSHHHHHHHHHH

Expression System HEK293
Molecular Weight Theoretical: 20.1kDa Actual: 24-30kDa
Purity

>90% by SDS-PAGE

Endotoxin <1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.
Reconstitution Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage
  • 12 months from date of receipt, -20 ℃ to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.  
  • Please avoid repeated freeze-thaw cycles. 

Background

Lymphocyte-specific protein tyrosine kinase (LCK) is a member of the Src family of protein tyrosine kinases (PTKs). It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. LCK has emerged as one of the key molecules regulating T-cell functions. Studies using LCK knock-out mice or LCK-deficient T-cell lines have shown that LCK regulates the initiation of TCR signaling, T-cell development, and T-cell homeostasis. Because of the crucial role of LCK in T-cell responses, strategies have been employed to redirect LCK activity to improve the efficacy of chimeric antigen receptors (CARs) and to potentiate T-cell responses in cancer immunotherapy. In addition to the well-studied role of LCK in T cells, evidence has been accumulated suggesting that LCK is also expressed in the brain and in tumor cells, where it actively takes part in signaling processes regulating cellular functions like proliferation, survival and memory. Therefore, LCK has emerged as a novel druggable target molecule for the treatment of cancer and neuronal diseases. 

Shipping Notes
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 14043899687

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Lane G.
Whiting, US
★★★★★ 5
KONG; consistently sturdy!
Color: bone, Size: 1 Count (Pack of 1)
This toy is small enough for my 11 pound puppy and he loves it. It's also sturdy enough (as KONG products always are) to withstand his terrier jaws and ability to destroy most toys in under 5 minutes. Keeps him busy for hours.
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Reviewed in the United States on August 26, 2025
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Paula
Houston, US
★★★★★ 5
Tough reliable quality
Color: bone, Size: 1 Count (Pack of 1)
My dogs love these. Quality is good. You can put small treats in them for short activity.
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Reviewed in the United States on February 1, 2026
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Mary Kelleher
Carnegie, US
★★★★★ 5
Durable
Color: bone, Size: 1 Count (Pack of 1)
Perfect chew toy for my cat that thinks it’s a dog
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Reviewed in the United States on March 26, 2026
S
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sec682
Boise, US
★★★★★ 4
Wears out more quickly than standard versions
Color: bone, Size: 1 Count (Pack of 1), Color: bone, Size: 1 Count (Pack of 1)
While my puppy loved this bone and it was a good starter toy, it didn't last long. Our lab puppy loves to chew - especially when we stuffed the ends on this bone. After about 1.5 months of moderate use, she ended up chewing off and swallowing a small chunk of this bone, which she thankfully passed without issue. The material of this bone is intentionally softer than other kong toys, so it breaks down easier, and you will need to inspect it for wear more frequently. We have since upgraded to the large super chewer version for her, and she still loves it.
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Reviewed in the United States on July 22, 2025
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Verified Purchase
J Kowlessar
Lake Worth, US
★★★★★ 5
Teething proof!
Color: bone, Size: 1 Count (Pack of 1)
My 9 month old mini dachshund loves this bone. Holds up impeccably. Great price. Thank you Kong!
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Reviewed in the United States on February 25, 2026

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