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Description
Caspase-3 Recombinant Rabbit mAb (S-493-3)Product Specification Host Rabbit Antigen Caspase 3 Synonyms Apopain, Cysteine protease CPP32, Protein Yama, SREBP cleavage activity 1 (SCA 1), CASP3, CPP32 Immunogen Recombinant Protein Location Cytoplasm Accession P42574 Clone Number S 493 3 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol,
Product Specification
| Host | Rabbit |
| Antigen | Caspase-3 |
| Synonyms | Apopain, Cysteine protease CPP32, Protein Yama, SREBP cleavage activity 1 (SCA-1), CASP3, CPP32 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm |
| Accession | P42574 |
| Clone Number | S-493-3 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC | 1:500-1:2000 |
Background
The CASP3 protein is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6 and 7; and the protein itself is processed and activated by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
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