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Description
KCND2 Recombinant Rabbit mAb (S-3102-32)Product Specification Host Rabbit Antigen KCND2 Synonyms A type voltage gated potassium channel KCND2; Potassium voltage gated channel subfamily D member 2; Voltage gated potassium channel subunit Kv4. 2; KIAA1044 Immunogen Synthetic Peptide Location Cell membrane, Cell projection Accession Q9NZV8 Clone Number S 3102 32 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Ms, Rt Positive Sample unboiled mouse brain, unboiled
Product Specification
| Host | Rabbit |
| Antigen | KCND2 |
| Synonyms | A-type voltage-gated potassium channel KCND2; Potassium voltage-gated channel subfamily D member 2; Voltage-gated potassium channel subunit Kv4.2; KIAA1044 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane, Cell projection |
| Accession | Q9NZV8 |
| Clone Number | S-3102-32 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Ms, Rt |
| Positive Sample | unboiled mouse brain, unboiled mouse cerebellum, unboiled rat brain, unboiled rat cerebellum |
| Predicted Reactivity | Rb, Ft |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms, Rt |
| IHC-P | 1:500 | Ms, Rt |
Background
KCND2, also known as Kv4.2, is a voltage-gated, Shal-type potassium channel subunit that generates rapidly inactivating A-type outward K⁺ currents essential for the early repolarization phase (phase 1) of cardiac and neuronal action potentials; it is expressed most abundantly in brain and heart, forms tetrameric channels at the plasma membrane (including dendritic spines and T-tubules) where it interacts with auxiliary subunits and the actin-binding protein FLNC to fine-tune excitability, and its gain- or loss-of-function has been linked to cardiac arrhythmias, epilepsy and developmental neurological disorders.
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