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Description
Phospho-CaMKII (Thr286) Recombinant Rabbit mAb (S-1251-278)Product Specification Host Rabbit Antigen Phospho CaMKII (Thr286) Synonyms Calcium calmodulin dependent protein kinase type II subunit alpha; CaM kinase II subunit alpha; CaMK II subunit alpha; CAMKA; KIAA0968; CAMK2A Immunogen Synthetic Peptide Location Synapse Accession Q9UQM7 Clone Number S 1251 278 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample Human brain, mouse brain, rat brain Purification Protein
Product Specification
| Host | Rabbit |
| Antigen | Phospho-CaMKII (Thr286) |
| Synonyms | Calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II subunit alpha; CaMK-II subunit alpha; CAMKA; KIAA0968; CAMK2A |
| Immunogen | Synthetic Peptide |
| Location | Synapse |
| Accession | Q9UQM7 |
| Clone Number | S-1251-278 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Human brain, mouse brain, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000 | Ms, Rt |
Background
Phospho-CaMKII (Thr286) refers to the phosphorylated form of the Ca2+/calmodulin-dependent protein kinase II (CaMKII) at threonine residue 286. CaMKII is a multifunctional serine/threonine protein kinase that plays a crucial role in various cellular processes, particularly in the heart and brain. When phosphorylated at Thr286, CaMKII undergoes autophosphorylation, which enhances its activity and allows it to function in a Ca2+-independent manner. This phosphorylated state is essential for the regulation of cardiac myocyte contraction, synaptic plasticity, and memory formation. Abnormal phosphorylation of CaMKII at Thr286 has been implicated in several pathological conditions, including heart failure and arrhythmias, making it a potential therapeutic target for cardiovascular diseases.
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