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Description
Anti-CD49d Monoclonal Antibody(Natalizumab)Product Specification Host Human Accession P13612 Clone Number S SC023 Antibody Type Recombinant mAb Isotype IgG4,k Application Blocking of Integrin alpha 4 signaling Functional assays Purification Protein A Concentration 2 mg ml Endotoxin <1EU mg Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, containing no preservative Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied Background
Product Specification
| Host | Human |
| Accession | P13612 |
| Clone Number | S-SC023 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG4,k |
| Application | Blocking of Integrin alpha-4 signaling Functional assays |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Background
Natalizumab, is a monoclonal antibody which targets a protein called α4β1 integrin on white blood cells involved in inflammation. By attaching to integrin, natalizumab is thought to stop white blood cells from entering the brain and spinal cord tissue, thereby reducing inflammation and the resulting nerve damage.
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4.8 ★★★★★
Based on 226 reviews
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Product Reviews
★★★★★ 5
Cute and educational
Format: Board book
Besides being such a cute story, the tactile features in this book hold my one year old's attention span: the different size pages and hole cut-outs. Also good for introducing days of the week, numbers, and fruits.
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Reviewed in the United States on March 25, 2026
★★★★★ 5
Beautiful colors
Format: Hardcover
Great book!
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Reviewed in the United States on May 28, 2026
★★★★★ 5
exceptional, very highly recommended character-driven literary family drama
Format: Kindle
Whistler by Ann Patchett is an exceptional, very highly recommended character-driven literary family drama which will definitely be one of the best books I've read this year. In Whistler Patchett has given us a beautifully written, eloquent, insightful and sensitive story encompassing the complexity of families, connections, and relationships over time. I love everything about this book.
As they were visiting the Metropolitan Museum of Art, Daphne Fuller's retired husband Jonathan notices an older man following them and they discover he is Eddie Triplett, Daphne's former stepfather. She hasn't seen him for 44 years but immediately remembers her love for him and the bond they had for a couple years. The two also shared a traumatic experience when she was nine and they were in a car accident. Immediately after this Daphne's mother divorced Eddie and he disappeared from her life. After this chance meeting and reconnection, Daphne immediately and understandably needs to see and tell her younger sister, Leda, about it.
The sisters had a complicated childhood that Daphne never felt was very happy. Daphne and Leda's biological father, Buddy Zabriskie, was a deep-sea fisherman and left the family early, although the girls had a relationship with him. Then their mother married Eddie and both girls loved him for the brief time he was in their lives. Their third and final stepfather, Lucas Ekker, still lives with her mother in Massachusetts and they had two sons. The two sisters were done with stepfathers at this point.
As the narrative unfolds, Daphne and Eddie continue to meet and restore their relationship as father and daughter, but now as adults. While following the present day events, Interstitial chapters jump back in time when Eddie was her stepfather and cover the events from when they were in the car accident. It is during these interludes back in time that were learn the story of Whistler and also see the deep connection between Eddie and Daphne. Events in both the past and present show how complicated interpersonal relationships are, how little we truly understand of our past, and, ultimately, how fragile life can be.
Because this is a character-driven story, all the characters are portrayed as realistic, fully realized individuals with strengths and weaknesses. The narrative examines relationships, choices made in both the past and present and how many seemingly small and inconsequential moments can follow us our whole lives. It also gently shows how being recognized and understood by another person, even for a short period of time, can change your life and theirs.
Whistler by Ann Patchett is a wonderful choice for everyone who enjoys thoughtful, sensitive, character-driven literary novels. Thanks to HarperCollins for providing me with an advance reader's copy via Edelweiss. My review is voluntary and expresses my honest opinion.
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Reviewed in the United States on June 2, 2026
★★★★★ 4
Another good Patchett book
Format: Kindle
Thanks go to the publisher and Netgalley for an advance copy of Whistler.
I enjoyed this book. The story and characters, and references the the publishing world. I wanted to like it (at a 5 star level) more than I did. But overall, a good read.
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Reviewed in the United States on June 2, 2026
★★★★★ 5
Wonderful, Gripping, Suspenseful, and Miraculous!
Format: Hardcover
The first thing I thought when I started reading Ann Patchett’s new novel, “Whistler” was: “Oh no, this is SO GOOD it’s going to go by too quickly!” I was right, and the only remedy to that is to read it again – it’s that great.
Patchett has created a matryoshka doll of a novel with a story inside of a story inside of story, and they are ALL wonderful, gripping, suspenseful, and miraculous!
The inciting incident that sets off the story takes place in the Metropolitan Museum of Art in NYC. As Daphne and her husband Jonathan take in the art, Jonathan notices that they are being followed by an older man who turns out the be Daphne’s former stepfather, Eddie, whom she hasn’t seen in 44 years (since she was nine) but who was pivotal in how her life unfolded.
Through the narrative, Daphne, and her sister Leda, relive long forgotten memories from their brief but impactful time with Eddie, now understanding what they couldn’t as children.
Patchett has written about blended families, divorce, and stepparenting before, in her wonderful 2016 novel “Commonwealth”, and in some of the personal essays about her own childhood. So, she knows what she’s talking about!
Patchett beautifully evokes childhood nostalgia and skillfully portrays the way the past can sometimes seem more immediate than the present, highlighting reconnection, reconciliation, and grace.
Thank you yet again, Ann; this was just the book I needed right now!
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Reviewed in the United States on June 2, 2026