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Description
LY9/CD229 Recombinant Rabbit mAb (SDT-2393-47)Product Specification Host Rabbit Antigen LY9 CD229 Synonyms T lymphocyte surface antigen Ly 9; Cell surface molecule Ly 9; Lymphocyte antigen 9; SLAM family member 3 (SLAMF3); Signaling lymphocytic activation molecule 3 Immunogen Recombinant Protein Location Cell membrane Accession Q9HBG7 Clone Number SDT 2393 47 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample Daudi, Jurkat Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | LY9/CD229 |
| Synonyms | T-lymphocyte surface antigen Ly-9; Cell surface molecule Ly-9; Lymphocyte antigen 9; SLAM family member 3 (SLAMF3); Signaling lymphocytic activation molecule 3 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | Q9HBG7 |
| Clone Number | SDT-2393-47 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | Daudi, Jurkat |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20°C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:1000 | Hu |
Background
CD229, also known as LY9 or SLAMF3, is a 120 kDa type I transmembrane glycoprotein of the SLAM subgroup of the CD2 family, expressed on T, B, NK, dendritic and stem cells, that functions as a self-ligand through homophilic binding of its N-terminal IgV-like domain to regulate immune responses. Upon engagement, phosphorylation of two ITSM motifs in its long cytoplasmic tail recruits the adaptor proteins SAP or EAT-2 (or the phosphatases SHP-2/SHIP1), leading to signals that can either enhance or inhibit leukocyte activation, differentiation, cytokine production and cytotoxicity, depending on cellular context, and thereby controls processes such as T-cell adhesion and immunological synapse formation, Th17 polarization, maintenance of peripheral tolerance and prevention of autoimmunity, while its overexpression on malignant plasma and memory B cells has made CD229 a prognostic biomarker and CAR-T target in multiple myeloma and other B-cell malignancies.
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