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Description
Alexa Fluor® 647 Mouse Anti-Human CD41a Antibody (S-R554)Product Specification Host Mouse Antigen CD41a Synonyms Integrin alpha IIb; GPalpha IIb (GPIIb); Platelet membrane glycoprotein IIb; CD41; GP2B; ITGAB; ITGA2B Accession P08514 Clone Number S R554 Antibody Type Mouse mAb Isotype IgG1 Application FCM Reactivity Hu Purification Protein G Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Mouse |
| Antigen | CD41a |
| Synonyms | Integrin alpha-IIb; GPalpha IIb (GPIIb); Platelet membrane glycoprotein IIb; CD41; GP2B; ITGAB; ITGA2B |
| Accession | P08514 |
| Clone Number | S-R554 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1 |
| Application | FCM |
| Reactivity | Hu |
| Purification | Protein G |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5 μl per million cells in 100μl volume |
Background
CD41, also known as Integrin α-IIb or GPαIIb, is a protein expressed on platelets and megakaryocytes. CD41 is a component of the platelet membrane glycoprotein complex and non-covalently associates with CD61 (Integrin β-3) to form the αIIbβ3 complex, which is an essential integrin in platelets. It plays a crucial role in platelet activation and aggregation, particularly during thrombus formation and hemostasis. In clinical practice, the detection of CD41 is essential for diagnosing and studying platelet-related diseases. For instance, immunostaining for CD41 can help identify micromegakaryocytes, which might be confused with primitive megakaryocytes or lymphocytes in Wright-Giemsa staining, leading to missed diagnoses. CD41 staining can significantly improve the detection rate of micromegakaryocytes, which is crucial for the diagnosis and therapeutic monitoring of certain hematological disorders.
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