Pay in installments of $25.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 9 - Aug 14
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
BCRP/ABCG2 Recombinant Rabbit mAb (S-2365-67)Product Specification Host Rabbit Antigen BCRP ABCG2 Synonyms Broad substrate specificity ATP binding cassette transporter ABCG2; ATP binding cassette sub family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance associated protein; Placenta specific ATP binding cassette transporter; Urate exporter; CD338; ABCP; BCRP1; MXR Immunogen Recombinant Protein Location Mitochondrion, Cell membrane Accession Q9UNQ0 Clone Number S
Product Specification
| Host | Rabbit |
| Antigen | BCRP/ABCG2 |
| Synonyms | Broad substrate specificity ATP-binding cassette transporter ABCG2; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporter; CD338; ABCP; BCRP1; MXR |
| Immunogen | Recombinant Protein |
| Location | Mitochondrion, Cell membrane |
| Accession | Q9UNQ0 |
| Clone Number | S-2365-67 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | A549, PANC-1, mouse liver, rat liver |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt |
Background
The breast cancer resistance protein (BCRP/ABCG2), encoded by the ABCG2 gene, is a 655-amino-acid, 72–75 kDa half-transporter (a member of the ABC transporter superfamily G subfamily) that forms homodimers or oligomers to function as an ATP-dependent efflux pump actively transporting a broad range of substrates—including anticancer drugs (e.g., mitoxantrone, topotecan), endogenous compounds (e.g., estrone-3-sulfate, uric acid), and xenobiotics—across apical membranes of tissues such as the placenta, intestine, liver, kidney proximal tubules, and brain microvascular endothelium, thereby contributing to drug absorption, distribution, and elimination, protecting against xenobiotic exposure, and conferring multidrug resistance in cancer, particularly acute myeloid leukemia.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy