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Description
Biotin Rat Anti-Mouse Thy1 (CD90) Antibody (S-4038)Product Specification Host Rat Antigen Thy1 (CD90) Synonyms Thy 1 membrane glycoprotein; Thy 1 antigen; Thy 1 Location Cell membrane Accession P01831 Clone Number S 4038 Antibody Type Rat mAb Isotype IgG2a Application FCM Reactivity Ms Positive Sample Fresh C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 5 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability & Storage 12 months
Product Specification
| Host | Rat |
| Antigen | Thy1 (CD90) |
| Synonyms | Thy-1 membrane glycoprotein; Thy-1 antigen; Thy-1 |
| Location | Cell membrane |
| Accession | P01831 |
| Clone Number | S-4038 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | Fresh C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.5 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1μg per million cells in 100μl volume | Ms |
Background
Thy1 (also known as CD90) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein widely expressed on the surface of various cell types and belongs to the immunoglobulin superfamily; it was originally named after its discovery in mouse thymocytes. As a critical marker for stem cells and specific differentiated cells, Thy1 is highly expressed on hematopoietic stem cells, mesenchymal stem cells (MSCs), neurons, fibroblasts, and activated T cells, with its functions varying significantly depending on the cell type: in the nervous system, it participates in axon growth, synaptic plasticity, and neural repair; in the immune system, it regulates T cell activation, adhesion, and migration; and in stem cell research, it serves as a key surface antigen for identifying and isolating MSCs (typically characterized as CD90-positive). Although its precise downstream signaling mechanisms remain not fully understood due to the lack of a transmembrane domain, Thy1 is generally believed to mediate cell-cell and cell-matrix adhesion by interacting with extracellular matrix components or other membrane proteins, thereby influencing cell proliferation, differentiation, and tissue homeostasis, making it a vital target in regenerative medicine, neurobiology, and oncology.
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