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Description
FITC Rabbit Anti-FMC63 Antibody (S-2163-77)Product Specification Host Rabbit Antigen FMC63 scFv Immunogen Recombinant Protein Clone Number S 2163 77 Antibody Type Recombinant mAb Isotype IgG Application FCM Purification Protein A Concentration 0. 2 mg ml Conjugation FITC Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied Dilution application dilution species FCM 5l per million cells in
Product Specification
| Host | Rabbit |
| Antigen | FMC63 scFv |
| Immunogen | Recombinant Protein |
| Clone Number | S-2163-77 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Species independent |
Background
FMC63 scFv (single-chain variable fragment) is a recombinant protein derived from the variable regions (VH and VL) of the anti-CD19 monoclonal antibody FMC63, linked by a flexible peptide spacer (e.g., (Gly₄Ser)₃). It specifically binds to the B-cell surface antigen CD19 with high affinity (KD ~1-10 nM) and is a key targeting component in FDA-approved CAR-T therapies, such as Kymriah®. The humanized FMC63 scFv retains potent antigen recognition while minimizing immunogenicity, making it highly effective in treating B-cell malignancies, including acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL). Ongoing research focuses on optimizing its affinity, stability, and functionality to enhance the safety and efficacy of CAR-T cell therapies.
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4.4 ★★★★★
Based on 9 reviews
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Product Reviews
★★★★★ 5
Colonialism not dead yet
This is a review of the 2004 Grove paperback edition of Frantz Fanon’s The Wretched of the Earth
The Wretched of the Earth is the most famous work of Algerian revolutionary Franz Fanon (1925-1961) finished and published shortly before his death (he died of leukemia). Fanon is known above all as a theorist of revolutionary violence and a champion of its therapeutic good for the oppressed. However, this book is not about armed struggle only; it covers many other topics: theory of class conflict in colonies, revolutionary process and subjects of social change in the Third World, the future of new independent states (former colonies), strategies of building Third World—First World relations in a right way, the relationship between the struggle for national culture and national liberation struggles, consequences of colonialism for both the colonizer and the colonized, etc. It’s a book of an angry man; the author's revolutionary pathos and standing with the oppressed (‘the wretched of the earth’) are noticeable.
Though Fanon wrote his book drawing on the experience of the Africa of the 1950s an acute reader can easily notice similarities and parallels with what’s going on in the underdeveloped countries all over the world.
The book can be of particular use for anthropologists, historians, philosophers, sociologists, as well as for those interested in cultural studies. I prefer Richard Philcox’s translation to the one published in 1963. Citizens of the global South can skip Jean-Paul Sartre’s preface; let the author speak for himself.
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Reviewed in the United States on September 17, 2019
★★★★★ 4
Influential and Insightful
Frantz Fanon's The Wretched of the Earth is an important document in the history of imperialism capturing the state of the Algerian revolution and the struggle for independence in the Third World at a crucial time. The year was 1961, and the book was published just before Fanon's premature death. Algeria was a year away from independence. The Congo had just achieved a travesty of independence. The Cuban revolution was still fresh.
Fanon was born in Martinique but was fully committed to the Algerian cause by the end of his life. His insights into the pitfalls threatening newly-independent nations have proved to be uncannily accurate. His voice is of his time and ahead of his time.
I would recommend this book to those wanting to learn more about the Algerian War and to those curious about the huge effect of this book on the leftists of the 1960s.
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Reviewed in the United States on September 28, 2013
★★★★★ 5
A SIXTIES CLASSIC WE HAVE MOVED ON FROM OR BACK OF/
Format: Paperback
i am 90 years old. i was a student in the 60s but i had already served in the military so i was already in my 30s. Which meant with a wife and twins i was more concerned with earning a living and finishing my doctorate than participating BUT it was a time when we swung one way as a nation and we were part of the post war swing of the world. The world had developed empires, WW1 began their downfall, ww2 pretty much finished the rest BUT it opened the door for new imperialism. On one hand colonialism melted away. The greatest empire ever, the British faded to legend and an island itself breaking up. American imperialism sprouted along with Soviet. And now China and Russia. One old model, Russia, one new model China. But the world i cyclical not progressive so China may become another imperial power. Fanon is an antidote as are other writers of the 60s so good to see new editions. Many rebels are now out of print. History is always ignored but it is always present.
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Reviewed in the United States on July 12, 2022
★★★★★ 5
An Important Text for All Those Engaged in The Struggle
Format: Paperback
The type of text that can bring about a breakthrough in consciousness, it places world affairs in perspective for the seeker of an authentic African consciousness.
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Reviewed in the United States on May 19, 2025
★★★★★ 5
Surprisingly fun and informative- a good series!
Format: Paperback
Bought this and the Paris book for an 11 year old girl before a trip to those cities. Although I felt like some of the quiz activities seemed a little too easy for her, the book provided an incredible array of information (current, historical, cultural, cuisine etc) presented in an entertaining way. She seemed to enjoy the book before and during the trip. She likes to read, and enjoyed getting a preview and information about of some of the places and things they would see. Would buy another in the future if they plan to travel to somewhere else covered in the series.
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Reviewed in the United States on December 19, 2023
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