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Description
LICAM Recombinant Rabbit mAb, PBS Only (SDT-2594-39)Product Specification Host Rabbit Antigen LICAM Synonyms Neural cell adhesion molecule L1; N CAM L1; NCAM L1; CD171; CAML1; MIC5; L1CAM Immunogen Recombinant Protein Location Cell membrane Accession P32004 Clone Number SDT 2594 39 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample HeLa Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability
Product Specification
| Host | Rabbit |
| Antigen | LICAM |
| Synonyms | Neural cell adhesion molecule L1; N-CAM-L1; NCAM-L1; CD171; CAML1; MIC5; L1CAM |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P32004 |
| Clone Number | SDT-2594-39 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | HeLa |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution,4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu |
| IHC-P | 1:250 | Hu |
Background
LICAM (L1 cell adhesion molecule) is a 200–220 kDa transmembrane glycoprotein of the immunoglobulin superfamily that functions as a pivotal regulator of neural development—guiding neuronal migration, axon outgrowth and fasciculation via homophilic and heterophilic interactions with integrins and other adhesion receptors—and, when re-expressed in cancers such as glioblastoma, lung, endometrial and renal carcinomas, is proteolytically cleaved into soluble ectodomain and cytoplasmic fragments that activate integrin–FAK–GRB2–SOS–RAS signaling, thereby enhancing tumor-cell motility, invasion, trans-endothelial migration and metastasis and serving as an independent marker of poor prognosis and a potential therapeutic target.
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