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Description
HIRA Recombinant Rabbit mAb (S-2928-13)Product Specification Host Rabbit Antigen HIRA Synonyms Protein HIRA; TUP1 like enhancer of split protein 1; DGCR1; HIR; TUPLE1 Immunogen Synthetic Peptide Location Nucleus Accession P54198 Clone Number S 2928 13 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt, Mk Positive Sample HeLa, HeLa, K562, HEK 293, 293T, HCT 116, mouse brain, rat brain, COS 7 Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | HIRA |
| Synonyms | Protein HIRA; TUP1-like enhancer of split protein 1; DGCR1; HIR; TUPLE1 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P54198 |
| Clone Number | S-2928-13 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HeLa, HeLa, K562, HEK-293, 293T, HCT 116, mouse brain, rat brain, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
Background
HIRA (Histone Cell Cycle Regulator) is a conserved histone chaperone that forms a multi-subunit complex—typically including UBN1, CABIN1, and ASF1a—to deposit the histone variant H3.3 into chromatin independently of DNA replication, thereby modulating nucleosome dynamics at transcriptionally active promoters, enhancers, and gene bodies; by stabilizing open chromatin states, HIRA underlies gene activation, embryonic development, stress-responsive transcription, senescence-associated heterochromatin formation, and DNA-damage repair, while its dysregulation or haploinsufficiency at human chromosome 22q11.21 has been linked to DiGeorge syndrome and tumorigenesis.
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