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Description
CD19 Mouse mAb (S-1039-46)Product Specification Host Mouse Antigen CD19 Synonyms B lymphocyte antigen CD19, LE CD19, B lymphocyte surface antigen B4, Differentiation antigen CD19, T cell surface antigen Leu 12 Immunogen Recombinant Protein Location Cell membrane Accession P15391 Clone Number S 1039 46 Antibody Type Mouse mAb Isotype IgG1,k Application WB, IHC P, ICC, FCM, IF Reactivity Hu Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Mouse |
| Antigen | CD19 |
| Synonyms | B-lymphocyte antigen CD19, LE-CD19, B-lymphocyte surface antigen B4, Differentiation antigen CD19, T-cell surface antigen Leu-12 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P15391 |
| Clone Number | S-1039-46 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | WB, IHC-P, ICC, FCM, IF |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC-P | 1:500-1:1000 | |
| ICC | 1:500 | |
| FCM | 1:2000 | |
| IF | 1:500 |
Background
The CD19 antigen plays an important role in clinical oncology. In normal cells, it is the most ubiquitously expressed protein in the B lymphocyte lineage. CD19 expression is induced at the point of B lineage commitment during the differentiation of the hematopoietic stem cell, and its expression continues through preB and mature B cell differentiation until it is finally down-regulated during terminal differentiation into plasma cells. CD19 expression is maintained in B-lineage cells that have undergone neoplastic transformation, and therefore CD19 is useful in diagnosis of leukemias and lymphomas using monoclonal antibodies (mAbs) and flow cytometry [PMID: 8528044].
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