BRCA1 Recombinant Mouse mAb (S-4707)

BRCA1 (Breast Cancer gene 1) is a critical tumor suppressor protein encoded by the BRCA1 gene in humans, playing an indispensable role in maintaining genomic stability primarily through its involvement in the high-fidelity repair of double-strand DNA breaks via homologous recombination. Functioning as a scaffold within a large multiprotein complex, BRCA1 interacts with key partners such as BARD1, PALB2, and RAD51 to coordinate cell cycle checkpoints, particularly at the G2/M transition, ensuring that cells do not divide with damaged DNA, while also participating in transcriptional regulation and ubiquitination processes; consequently, inherited loss-of-function mutations in the BRCA1 gene severely compromise these DNA repair mechanisms, leading to an accumulation of genetic errors and a significantly elevated lifetime risk of developing hereditary breast and ovarian cancers, which has made the protein a central focus for both genetic screening protocols and the development of targeted therapies like PARP inhibitors that exploit synthetic lethality in BRCA1-deficient tumors.