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Description
IL-17A&IL-17F Heterodimer Protein, RatProduct Specification Species Rat Synonyms IL 17A, Interleukin 17A, CTLA 8, IL 17, IL 17F, Interleukin 17F, Cytokine ML 1, IL17A&IL17F Accession Q61453 (IL 17A)Q5BJ95 (IL 17F) Amino Acid Sequence Ala18 Ser150(IL 17A) Arg29 Ala161 (IL 17F) Expression System HEK293 Molecular Weight 12 25 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7.
Product Specification
| Species | Rat |
| Synonyms | IL-17A, Interleukin-17A, CTLA-8, IL-17, IL-17F, Interleukin-17F, Cytokine ML-1, IL17A&IL17F |
| Accession | Q61453 (IL-17A)、Q5BJ95 (IL-17F) |
| Amino Acid Sequence | Ala18-Ser150(IL-17A) |
| Expression System | HEK293 |
| Molecular Weight | 12-25 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Annu Rev Immunol. 2009:27:485-517. |
Background
Interleukin-17A (IL-17A), also called cytotoxic T-lymphocyte-associated antigen 8 (CTLA8), and IL-17F are proinflammatory cytokines primarily secreted by activated T cells. Both cytokines can modulate the activities of NF-kappaB and mitogen-activated protein kinases, playing key roles in inflammatory signaling pathways. They are capable of stimulating the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), while also enhancing the production of nitric oxide (NO). Both IL-17A and IL-17F exist in both glycosylated and nonglycosylated forms, which may affect their biological activities. These two cytokines often work in concert to amplify inflammatory responses in the body. Elevated levels of IL-17A and IL-17F are associated with various chronic inflammatory diseases. Such diseases include rheumatoid arthritis, psoriasis, and multiple sclerosis, highlighting their significance in pathological processes.
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