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Description
p21 Waf1/Cip1 Recombinant Rabbit mAb, PBS Only (SDT-1349-71)Product Specification Host Rabbit Antigen p21 Waf1 Cip1 Synonyms WAFT; Cyclin dependent kinase inhibitor 1; CDK interacting protein 1; MDA 6; p21; CDKN1A; CAP20; CDKN1; CIP1; MDA6; PIC1; SDI1 Immunogen Synthetic Peptide Location Nucleus Accession P38936 Clone Number SDT 1349 71 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, IP, IF Reactivity Hu Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | p21 Waf1/Cip1 |
| Synonyms | WAFT; Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; MDA-6; p21; CDKN1A; CAP20; CDKN1; CIP1; MDA6; PIC1; SDI1 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P38936 |
| Clone Number | SDT-1349-71 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, IP, IF |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IP | 1:50 | |
| IHC-P | 1:200 | |
| ICC | 1:500 | |
| IF | 1:100 |
Background
p21Cip1 (alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes [PMID: 8259214], though is primarily associated with inhibition of CDK2 [PMID: 8259214, PMID: 8242751]. p21 represents a major target of p53 activity and thus is associated with linking DNA damage to cell cycle arrest [PMID: 9822382]. his protein is encoded by the CDKN1A gene located on chromosome 6 (6p21.2) in humans.
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