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Description
Alexa Fluor® 488 Mouse Anti-Human CD1a Antibody (S-R527)Product Specification Host Mouse Antigen CD1a Synonyms T cell surface glycoprotein CD1a; T cell surface antigen T6 Leu 6 (hTa1 thymocyte antigen); CD1A Location Cell membrane Accession P06126 Clone Number S R527 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample MOLT 4 Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300
Product Specification
| Host | Mouse |
| Antigen | CD1a |
| Synonyms | T-cell surface glycoprotein CD1a; T-cell surface antigen T6/Leu-6 (hTa1 thymocyte antigen); CD1A |
| Location | Cell membrane |
| Accession | P06126 |
| Clone Number | S-R527 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | MOLT-4 |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
CD1a is a 49-kDa type I transmembrane glycoprotein of the non-polymorphic CD1 family that folds into three extracellular Ig-like domains (α1–α3) stabilized by disulfide bonds and a short cytoplasmic tail containing the YXXZ-based tyrosine motif that drives its trafficking from the plasma membrane to late endosomes, where at pH 4.5–5.5 it loads endogenous or microbial lipid/glycolipid antigens—such as sphingolipids, mycoketides, lipopeptides or sulfatides—into its narrow hydrophobic groove; these CD1a–lipid complexes are then recycled to the cell surface for surveying by clonotypically diverse αβ and γδ T cells (including TRAV1-2− MAIT cells, NKT subsets and autoreactive TCRs) whose activation contributes to thymic selection, skin immunity, peripheral tolerance and host defense against mycobacteria, while dysregulated CD1a expression on Langerhans cells and other dendritic cells fuels inflammatory skin disorders like psoriasis, atopic dermatitis and cutaneous T-cell lymphoma, making CD1a a diagnostic marker (clone O10) and emerging therapeutic target.
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