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Description
Alexa Fluor® 488 Rat Anti-Mouse CD3 Antibody (17A2)Product Specification Host Rat Antigen CD3 Synonyms T cell surface glycoprotein CD3 zeta chain; T cell receptor T3 zeta chain; Cd3z; Tcrz; Cd247 Location Cell membrane Accession P24161 Clone Number 17A2 Antibody Type Rat mAb Isotype IgG2b Application FCM Reactivity Ms Positive Sample BALB c mouse splenocytes Purification Protein G Concentration 0. 05mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin
Product Specification
| Host | Rat |
| Antigen | CD3 |
| Synonyms | T-cell surface glycoprotein CD3 zeta chain; T-cell receptor T3 zeta chain; Cd3z; Tcrz; Cd247 |
| Location | Cell membrane |
| Accession | P24161 |
| Clone Number | 17A2 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD3, also known as the cluster of differentiation 3, is a protein complex found on the surface of T cells, playing a crucial role in the immune system. It consists of four distinct chains: CD3γ, CD3δ, CD3ε, and CD3ζ. These chains form a complex that associates noncovalently with the T-cell receptor (TCR) to form the TCR complex, which is essential for recognizing antigens presented by major histocompatibility complex (MHC) molecules. When the TCR binds to an antigen-MHC complex, the CD3 complex transmits signals into the T cell, initiating a cascade of intracellular events that lead to T cell activation, proliferation, and differentiation. This process is vital for the immune response against pathogens and abnormal cells. CD3 is also involved in T cell development and maturation in the thymus. Given its central role in T cell function, CD3 is a key target in immunotherapy for diseases such as cancer and autoimmune disorders.
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