Pay in installments of $50.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 14 - Aug 19
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Invivo anti-Mouse IL-17A Recombinant mAbProduct Specification Host Mouse Antigen Mouse IL 17A Synonyms Interleukin 17A; IL 17; Cytotoxic T lymphocyte associated antigen 8 (CTLA 8); Il17a; Ctla8; Il17 Location Secreted Accession Q62386 Clone Number S R544 Antibody Type Mouse mAb Application in vivo IL 17A neutralization Reactivity Ms, Rt Purification Protein G Concentration 5 mg ml Endotoxin <2EU mg Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, containing no
Product Specification
| Host | Mouse |
| Antigen | Mouse IL-17A |
| Synonyms | Interleukin-17A; IL-17; Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8); Il17a; Ctla8; Il17 |
| Location | Secreted |
| Accession | Q62386 |
| Clone Number | S-R544 |
| Antibody Type | Mouse mAb |
| Application | in vivo IL-17A neutralization |
| Reactivity | Ms, Rt |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Endotoxin | <2EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage |
2 to 8 °C for 2 weeks under sterile conditions; -20 °C for 3 months under sterile conditions; -80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.
|
Background
IL-17A, also known as CTLA-8, is a significant member of the IL-17 cytokine family. It is primarily secreted by Th17 cells, but is also produced by various immune cells including CD8+ T cells, γδT cells, NKT cells, monocytes, and neutrophils. IL-17A plays a crucial role in host defense against a variety of bacterial and fungal pathogens and is also involved in allergic and autoimmune responses. It induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases, promoting neutrophilic inflammation and playing a role in antiviral responses. IL-17A is a homodimeric cytokine that binds with high affinity to IL-17RA, which is necessary for the biological activity of IL-17A. IL-17A is associated with multiple autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, asthma, and psoriasis. In cancer, IL-17A also plays a pathogenic role by recruiting myeloid-derived suppressor cells (MDSCs) to suppress antitumor immunity and promoting tumor growth in vivo through the induction of IL-6. Therefore, IL-17A is an important target in the treatment of related diseases, as it plays a significant role in inflammation, immune responses, and tumor development.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy