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Description
S-RMab® ATRX Recombinant Rabbit mAb (SDT-458-37)Product Specification Host Rabbit Antigen ATRX Synonyms ATP dependent helicase ATRX, X linked helicase II, X linked nuclear protein (XNP), Znf HX, RAD54L, XH2 Immunogen Recombinant Protein Location Nucleus Accession P46100 Clone Number SDT 458 37 Antibody Type Recombinant mAb Application IHC P, ICC Reactivity Hu, Ms, Rt Predicted Reactivity Or, Cz Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | ATRX |
| Synonyms | ATP-dependent helicase ATRX, X-linked helicase II, X-linked nuclear protein (XNP), Znf-HX, RAD54L, XH2 |
| Immunogen | Recombinant Protein |
| Location | Nucleus |
| Accession | P46100 |
| Clone Number | SDT-458-37 |
| Antibody Type | Recombinant mAb |
| Application | IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Or, Cz |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC | 1:250 | |
| ICC | 1:250 |
Background
ATRX is encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The ATRX gene is frequently mutated in a variety of tumors, including adult lower-grade gliomas, pediatric glioblastoma multiforme, pediatric adrenocortical carcinoma, osteosarcoma, and neuroblastoma. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis.
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