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Description
Mouse RBP4 Recombinant Rabbit mAb (S-3647)Product Specification Host Rabbit Antigen RBP4 Clone Number S 3647 Antibody Type Recombinant mAb Isotype IgG Application ELISA Reactivity Ms Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as supplied Dilution application dilution species ELISA 1: 5000 1: 10000 Ms
Product Specification
| Host | Rabbit |
| Antigen | RBP4 |
| Clone Number | S-3647 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | ELISA |
| Reactivity | Ms |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| ELISA | 1:5000-1:10000 | Ms |
Background
Mouse RBP4 (Retinol-Binding Protein 4) is a 21-kDa lipocalin-family protein featuring a conserved β-barrel structure that encapsulates all-trans retinol within its hydrophobic core. It mediates systemic vitamin A transport by forming a stabilizing complex with transthyretin (TTR), thereby extending its plasma half-life and preventing renal clearance. The mouse ortholog shares >90% sequence identity with human RBP4, including critical retinol-binding residues (e.g., Leu39, Phe61), but exhibits distinct kinetics in TTR binding compared to rat and human variants. Functionally, RBP4 ensures retinoid delivery to peripheral tissues, supporting vision, embryogenesis, and epithelial maintenance. Emerging evidence implicates mouse RBP4 as a modulator of glucose metabolism, with transgenic studies demonstrating its causative role in insulin resistance. Its dual roles in retinoid signaling and metabolic regulation make it a compelling therapeutic target for metabolic syndrome and ocular diseases in preclinical models.
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