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Description
Gelsolin Recombinant Rabbit mAb (S-2522-21)Product Specification Host Rabbit Antigen Gelsolin Synonyms AGEL; Actin depolymerizing factor (ADF); Brevin; GSN Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Secreted Accession P06396 Clone Number S 2522 21 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Mk Positive Sample HeLa, HT 29 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS,
Product Specification
| Host | Rabbit |
| Antigen | Gelsolin |
| Synonyms | AGEL; Actin-depolymerizing factor (ADF); Brevin; GSN |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton, Secreted |
| Accession | P06396 |
| Clone Number | S-2522-21 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Mk |
| Positive Sample | HeLa, HT-29 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:2000 | Hu |
Background
Gelsolin is a highly conserved, multifunctional actin-binding protein that severs, caps and nucleates actin filaments in response to Ca²⁺ and phosphoinositide signals, thereby orchestrating rapid cytoskeletal remodeling essential for cell motility, endocytosis, apoptosis and immune responses; it exists as both an 80–82 kDa cytoplasmic isoform and a slightly larger secreted plasma variant generated by alternative transcription initiation, each contributing to tissue repair and host defense by clearing actin filaments released from damaged cells, and its dysregulation—through mutation, proteolytic cleavage or altered expression—is implicated in cancer metastasis, neurodegeneration, amyloidosis and other human diseases.
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