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Description
EMMPRIN/CD147 His Tag Protein, HumanProduct Specification Species Human Antigen EMMPRIN CD147 Synonyms BSG, Extracellular matrix metalloproteinase inducer, Basigin (Ok Blood Group)Tumor Cell Derived Collagenase Stimulatory Factor, Leukocyte Activation Antigen M6, Collagenase Stimulatory Factor, CD147 Antigen, EMPRIN, TCSF, EMMPRIN, SLC7A11 Accession Q54A51 Amino Acid Sequence Ala22 His205, with C terminal 8*His
Product Specification
| Species | Human |
| Antigen | EMMPRIN/CD147 |
| Synonyms | BSG, Extracellular matrix metalloproteinase inducer, Basigin (Ok Blood Group)，Tumor Cell-Derived Collagenase Stimulatory Factor, Leukocyte Activation Antigen M6, Collagenase Stimulatory Factor, CD147 Antigen, EMPRIN, TCSF, EMMPRIN, SLC7A11 |
| Accession | Q54A51 |
| Amino Acid Sequence |
Ala22-His205, with C-terminal 8*His AAGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHGGGSHHHHHHHH
|
| Expression System | HEK293 |
| Molecular Weight | 25-33kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1.Gabison, E. E. et al. (2005) Biochimie 87:361. 2.Yurchenko, V. et al. (2006) Immunology 117:301. 3.Kasinrerk, W. et al. (1992) J. Immunol. 149:847. 4.Iacono, K.T. et al. (2007) Exp. Mol. Pathol.83:283. 5.Muramatsu T, Miyauchi T. Basigin (CD147): amultifunctional transmembrane protein involved in reproduction, neuralfunction, inflammation and tumor invasion. HistolHistopathol. 2003;18:981–7. |
Background
Extracellular matrix metalloproteinase (MMP) inducer (EMMPRIN), also known as basigin and CD147, is a 44-66 kDa, variably N- and O-glycosylated, type I transmembrane protein that belongs to the immunoglobulin superfamily. EMMPRIN belongs to the immunoglobulin (Ig) superfamily and is composed of two C2-like immunoglobulin extracellular domains, a transmembrane domain and a short cytoplasmic domain. The extracellular region, which contains three conserved N-glycosylation sites that are variably glycosylated, has been implicated in EMMPRIN self association, while the first Ig domain within this region is required for counter-receptor activity involved in MMP induction. The highly conserved transmembrane domain and the short cytoplasmic domain are thought to be implicated in interactions between EMMPRIN and other molecular partners within the membrane. In particular, EMMPRIN was shown to interact with integrins α3β1 and α6β1, enhancing the adhesion and spreading of the cell to the ECM and to caveolin-1 in lipid rafts leading to a decrease in EMMPRIN cell surface self association.
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