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Description
Biotin Rat Anti-Mouse CD146 Antibody (S-R606)Product Specification Host Rat Antigen CD146 Synonyms Cell surface glycoprotein MUC18; Gicerin; Melanoma cell adhesion molecule; Melanoma associated antigen MUC18; Muc18; Mcam Location Membrane Accession Q8R2Y2 Clone Number S R606 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 5 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS
Product Specification
| Host | Rat |
| Antigen | CD146 |
| Synonyms | Cell surface glycoprotein MUC18; Gicerin; Melanoma cell adhesion molecule; Melanoma-associated antigen MUC18; Muc18; Mcam |
| Location | Membrane |
| Accession | Q8R2Y2 |
| Clone Number | S-R606 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.5 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1μg per million cells in 100μl volume | Ms |
Background
CD146, also known as melanoma cell adhesion molecule (MCAM), hemopoietic cell adhesion molecule (HEMCAM), MUC18, S-Endo1, or A32 antigen, is a highly glycosylated type I transmembrane protein and a member of the immunoglobulin superfamily. It is primarily expressed on endothelial cells and plays a crucial role in cell adhesion, migration, and proliferation. CD146 is involved in various physiological processes, such as embryonic development and tissue maintenance, and its abnormal expression is associated with diseases like cancer and inflammatory disorders. It can act as a receptor for several ligands, including laminin 421, galectin-3, and S100A8/A9, and is also a co-receptor for pro-angiogenic factor receptors like VEGFR2 and PDGFR-β.
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Exchange/Return Notes
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