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Description
TPH-1 Recombinant Rabbit mAb (S-2287-143)Product Specification Host Rabbit Antigen TPH 1 Synonyms Tryptophan 5 hydroxylase 1; Tryptophan 5 monooxygenase 1; TPH; TPRH; TRPH; TPH1 Immunogen Synthetic Peptide Accession P17752 Clone Number S 2287 143 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Predicted Reactivity Rb Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03%
Product Specification
| Host | Rabbit |
| Antigen | TPH-1 |
| Synonyms | Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; TPH; TPRH; TRPH; TPH1 |
| Immunogen | Synthetic Peptide |
| Accession | P17752 |
| Clone Number | S-2287-143 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Predicted Reactivity | Rb |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu |
Background
TPH-1 (tryptophan hydroxylase-1) is a 51-kDa, biopterin-dependent and rate-limiting enzyme that catalyzes the hydroxylation of L-tryptophan to 5-hydroxytryptophan, thereby initiating peripheral serotonin synthesis in enterochromaffin cells, platelets, and mast cells; it is a homodimer whose activity is regulated by phosphorylation, allosteric cAMP-dependent mechanisms, and interaction with 14-3-3 proteins, and genetic or post-translational dysregulation of TPH-1 has been implicated in gastrointestinal disorders, cardiovascular fibrosis, and mood-related diseases.
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4.5 ★★★★★
Based on 30 reviews
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Product Reviews
★★★★★ 5
Wedding prop
The perfect touch for our wedding. Our dog loved them
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Reviewed in the United States on July 22, 2025
★★★★★ 2
Adorable but not sturdy :(
These are adorable and were perfect for a little dog wedding but... 3 days later and one has already come apart. My dog is not a big chewer so I was shocked to see it in pieces. She was able to detach the squeaker from inside. On a larger dog this would likely be a choking hazard.
I've had several other toys from Zippy Paws and never seen this happen.
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Reviewed in the United States on September 17, 2024
★★★★★ 5
The dogs loved it! Will buy again.
Style: Squeaky Chicken
My dogs have really enjoyed all the layers to this toy. It squeaks and has a noisy film on the inside of the cloth that they really like. The toy itself is very stiff and rigid but they like that. It’s been about 3 months and they recently broke through the pink layer so it lasts quite a while. It was a challenge for them to get the layer off once they had broken through the stitching so it would keep him occupied for a very long time.
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Reviewed in the United States on January 21, 2026
★★★★★ 5
My dog LOVES this, but...
Style: Squeaky Duck
My dog loved this right out of the box, she didn't learn to squeak it for a couple of hours, but she just stopped playing with her other toys, ragged as they may be...
My dog is a Manchester/hound dog mix, of some sort, I'm only sure about the Manchester, she resembles them in look, size, weight, and all else.
She weighs approximately 20-ish pounds, or so.
With that said, like I said, she loves it, so much so that within 16 waking hours after its arrival she brought me the inner squeaker, the body was in the kitchen. :)
She tore off the top part of the head and gained access to the squeaker, and EXACTLY as advertised and other reviews, it is a really good squeaky toy, she really doesn't seem to mind that the outer portion is gone, the (seemingly) durable squeaker might actually last.
She can still play with the 'body', the toy is made that when (not if) they rip off an appendage, the nentire innards WILL NOT come out. It's a well designed toy in that respect. So, at times she will play with that too, she has brought me the BODY several times too,
My dog is a really CRAZY chewer, she is somewhere under a year old and she will chew on anything that she is in front of her, including rocks, a blade of grass as she runs by, furniture legs, window sills, you name it, she has eaten it.
She is a problem dog, but we picked her, and we'd do the same if it was our kid, we wouldn't throw them out. :)
She has to be watched constantly, that is not the most fun, but, like they say, 'It is what it is'.
I mention all of that to show that even though she is a crazy chewer, the rubber portion of the toy is still 'with us', for now, I will update this if anything else develops, and I am sure it will.
Oh yeah, I really need to add, I don't think that the makers can make a chew toy 'outer' from anything that will last that long, not unless you go to a rope material, and I did not want that, it can be swallowed and cause more trouble. (Fabric can be swallowed too, but it's at least softer...)
So, really, more than likely you can't get any better than this if your dog is a crazy chewer too.
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Reviewed in the United States on July 1, 2023
★★★★★ 1
Awful Durability
Style: Squeaky Chicken
My dog had this toy for all of 30 minutes an COMPLETELY destroyed it. He is not an aggressive chewer, and has had plenty of rip and reveal toys from Bark Box last WEEKS. I thought I'd try out another brand, but I will be swiftly placing a Bark Box order. I am very disappointed in the durability and quality of this toy thay is supposed to survive non-agressive chewing. If I could give 0 stars, I would have.
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Reviewed in the United States on May 15, 2026
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