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Description
Prolactin receptor Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen Prolactin receptor Synonyms PRL R; PRLR Immunogen Synthetic Peptide Location Secreted Accession P16471 Antibody Type Polyclonal antibody Isotype IgG Application WB Reactivity Hu Positive Sample T 47D Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date
Product Specification
| Host | Rabbit |
| Antigen | Prolactin receptor |
| Synonyms | PRL-R; PRLR |
| Immunogen | Synthetic Peptide |
| Location | Secreted |
| Accession | P16471 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | T-47D |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
The prolactin receptor (PRLR) is a single-pass transmembrane cytokine receptor of the hematopoietic cytokine receptor superfamily that dimerizes upon binding its ligand prolactin, activating downstream JAK2–STAT5, MAPK and PI3K–AKT signaling cascades to regulate mammary gland development and lactation, reproductive behavior, immune modulation, and metabolic homeostasis in target tissues including breast, ovary, prostate, liver and adipose; structurally it comprises an extracellular N-terminal domain with two conserved disulfide-bridged cytokine receptor homology modules and a WSXWS motif critical for ligand recognition, a short transmembrane helix, and an intracellular cytoplasmic tail containing Box1/2 motifs required for JAK2 docking and phosphorylation of conserved tyrosines that recruit STAT5 and other signaling adaptors, while alternative splicing and proteolytic cleavage generate soluble isoforms that modulate prolactin bioavailability, and genetic or epigenetic dysregulation of PRLR expression or signaling is implicated in breast and prostate tumorigenesis, making it a potential therapeutic target.
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