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Description
Runx3 Recombinant Rabbit mAb (S-R356)Product Specification Host Rabbit Synonyms Runt related transcription factor 3, Acute myeloid leukemia 2 protein, Core binding factor subunit alpha 3 (CBF alpha 3), Oncogene AML 2, Polyomavirus enhancer binding protein 2 alpha C subunit (PEA2 alpha C; PEBP2 alpha C), SL3 3 enhancer factor 1 alpha C subunit, SL3 AKV core binding factor alpha C subunit, AML2, CBFA3, PEBP2A3 Location Cytoplasm, Nucleus Accession Q13761 Clone Number S R356 Antibody Type
Product Specification
| Host | Rabbit |
| Synonyms | Runt-related transcription factor 3, Acute myeloid leukemia 2 protein, Core-binding factor subunit alpha-3 (CBF-alpha-3), Oncogene AML-2, Polyomavirus enhancer-binding protein 2 alpha C subunit (PEA2-alpha C; PEBP2-alpha C), SL3-3 enhancer factor 1 alpha C subunit, SL3/AKV core-binding factor alpha C subunit, AML2, CBFA3, PEBP2A3 |
| Location | Cytoplasm, Nucleus |
| Accession | Q13761 |
| Clone Number | S-R356 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500 | null |
| IHC-P | 1:500 | null |
| IP | 1:50 | null |
Background
Runx3 is a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-YGYGGT-3' found in a number of enhancers and promoters,[6] and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer.
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