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Description
Rat Anti-Mouse CD71 Antibody (S-R684)Product Specification Host Rat Antigen CD71 Synonyms Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; Tfrc Location Cell membrane Accession Q62351 Clone Number S R684 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse bone marrow Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Rat |
| Antigen | CD71 |
| Synonyms | Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; Tfrc |
| Location | Cell membrane |
| Accession | Q62351 |
| Clone Number | S-R684 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse bone marrow |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:2000 | Ms |
Background
CD71, also known as the transferrin receptor 1 (TfR1), is a type II transmembrane glycoprotein that plays a crucial role in cellular iron uptake by binding to transferrin, which facilitates iron transport into the cell. This receptor is highly expressed on rapidly proliferating cells, including erythroid precursors, activated immune cells, and cancer cells, as these cells require significant iron for DNA synthesis and metabolic processes. In clinical contexts, CD71 is used as a marker for identifying immature red blood cells (such as proerythroblasts and reticulocytes) and is also associated with aggressive tumor growth in various cancers, including pancreatic and colon cancers. Additionally, studies have shown that CD71 expression on neutrophils can be linked to poor prognosis in pancreatic ductal adenocarcinoma (PDAC) patients, indicating its potential as a prognostic biomarker.
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