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Description
CD5 Recombinant Rabbit mAb ,PBS Only (SDT-2857-16)Product Specification Host Rabbit Antigen CD5 Synonyms T cell surface glycoprotein CD5; Lymphocyte antigen T1 Leu 1; LEU1 Immunogen Recombinant Protein Location Cell membrane Accession P06127 Clone Number SDT 2857 16 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms Positive Sample Jurkat, Molt 4, mouse spleen Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer
Product Specification
| Host | Rabbit |
| Antigen | CD5 |
| Synonyms | T-cell surface glycoprotein CD5; Lymphocyte antigen T1/Leu-1; LEU1 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P06127 |
| Clone Number | SDT-2857-16 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms |
| Positive Sample | Jurkat, Molt-4, mouse spleen |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:500 | Hu, Ms |
Background
CD5 is a 67 kDa type I cell surface glycoprotein that belongs to the scavenger receptor cysteine-rich (SRCR) family. It is expressed on all T cells and a subset of B cells known as B-1a cells. CD5 plays a crucial role in regulating T cell receptor (TCR) signaling and acts as a negative regulator of T cell activation. It helps fine-tune the threshold for T cell activation during thymocyte development and suppresses peripheral T cell activation by inhibiting TCR-proximal signaling. In B-1a cells, CD5 helps prevent self-reactivity by dampening B cell receptor (BCR) signals. The expression of CD5 is also associated with cell survival, apoptosis, and the development of regulatory T cells. Additionally, CD5 may be involved in the regulation of dendritic cell function and cytokine production.
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Exchange/Return Notes
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