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Description
Invivo Anti-Mouse BTLA (CD272) Recombinant mAbProduct Specification Host Mouse Antigen BTLA (CD272) Synonyms B and T lymphocyte attenuator; B and T lymphocyte associated protein; Btla Location Cell membrane Accession Q7TSA3 Clone Number S 3831 Antibody Type Mouse mAb Isotype IgG1 Application FCM, in vivo BTLA stimulation, in vivo BTLA blockade Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 5 mg ml Purity >95%(Determined by SDS PAGE) Endotoxin <1EU mg
Product Specification
| Host | Mouse |
| Antigen | BTLA (CD272) |
| Synonyms | B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; Btla |
| Location | Cell membrane |
| Accession | Q7TSA3 |
| Clone Number | S-3831 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1 |
| Application | FCM, in vivo BTLA stimulation, in vivo BTLA blockade |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95%(Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Dilution
| application | dilution | species |
| FCM | 1:200 | Ms |
Background
BTLA (CD272) is a ~34–43 kDa type-I transmembrane glycoprotein of the CD28/CTLA-4 Ig superfamily that is constitutively expressed on T, B, NK and dendritic cells, where it delivers inhibitory signals through two ITIMs and an ITSM in its cytoplasmic tail after binding its ligand HVEM (CD270), thereby attenuating T- and B-cell proliferation, cytokine production and cytolytic activity, recruiting SHP-1/SHP-2 phosphatases to maintain immune homeostasis and self-tolerance, and acting in concert with PD-1 and CTLA-4 as an immune-checkpoint axis whose down-regulation on tumor or autoreactive lymphocytes promotes immune evasion or autoimmune pathologies such as SLE.
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Exchange/Return Notes
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