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Description
Human NPTX2 Protein, His TagProduct Specification Species Human Synonyms Neuronal pentraxin 2, NP2, Neuronal pentraxin II (NP II) Accession P47972 Amino Acid Sequence Protein sequence (P47972, Gly16 Leu431, with C His Tag)
Product Specification
| Species | Human |
| Synonyms | Neuronal pentraxin-2, NP2, Neuronal pentraxin II (NP-II) |
| Accession | P47972 |
| Amino Acid Sequence | Protein sequence (P47972, Gly16-Leu431, with C-His Tag) GAQDSPAPGSRFVCTALPPEAVHAGCPLPAMPMQGGAQSPEEELRAAVLQLRETVVQQKETLGAQREAIRELTGKLARCEGLAGGKARGAGATGKDTMGDLPRDPGHVVEQLSRSLQTLKDRLESLEHQLRANVSNAGLPGDFREVLQQRLGELERQLLRKVAELEDEKSLLHNETSAHRQKTESTLNALLQRVTELERGNSAFKSPDAFKVSLPLRTNYLYGKIKKTLPELYAFTICLWLRSSASPGIGTPFSYAVPGQANEIVLIEWGNNPIELLINDKVAQLPLFVSDGKWHHICVTWTTRDGMWEAFQDGEKLGTGENLAPWHPIKPGGVLILGQEQDTVGGRFDATQAFVGELSQFNIWDRVLRAQEIVNIANCSTNMPGNIIPWVDNNVDVFGGASKWPVETCEERLLDL |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 47.4 kDa Observed MW: 55-70 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Neuronal Pentraxin 2 (NPTX2), also known as Neuronal Activity-Regulated Pentraxin (NARP), is a secreted protein predominantly expressed in neurons. It belongs to the pentraxin family and is rapidly induced by synaptic activity. Its primary function is at excitatory synapses, where it organizes the surface expression of AMPA-type glutamate receptors. By clustering these receptors, NPTX2 is crucial for strengthening synaptic connections and is a key mediator of homeostatic and experience-dependent plasticity. Dysregulation of NPTX2 is increasingly associated with various neurological disorders, including cognitive impairment, Alzheimer's disease, and schizophrenia.
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