SKU: 25741187176

IGF1 Receptor Recombinant Rabbit mAb (S-1617-146)

Sale price$90.00 Regular price$100.00
Save 10%

Pay in installments of $25.00 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Aug 12 - Aug 17

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

IGF1 Receptor Recombinant Rabbit mAb (S-1617-146)Product Specification Host Rabbit Antigen IGF1 Receptor Synonyms Insulin like growth factor 1 receptor; Insulin like growth factor I receptor (IGF I receptor); CD221; IGF1R Immunogen Recombinant Protein Location Cell membrane Accession P08069 Clone Number S 1617 146 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample MCF7, A431, HepG2, HeLa, HCT 116, MDA MB 231, HEK 293, C2C12, NIH 3T3, mouse brain, mouse

Product Specification


Host Rabbit
Antigen IGF1 Receptor
Synonyms Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor (IGF-I receptor); CD221; IGF1R
Immunogen Recombinant Protein
Location Cell membrane
Accession P08069
Clone Number S-1617-146
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu, Ms, Rt
Positive Sample MCF7, A431, HepG2, HeLa, HCT 116, MDA-MB-231, HEK-293, C2C12, NIH/3T3, mouse brain, mouse spleen, C6, rat brain
Predicted Reactivity Bv
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt

Background

The insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase that is widely expressed on the surface of human cells and plays a crucial role in cell growth, proliferation, and differentiation. It is activated by insulin-like growth factor 1 (IGF-1) and IGF-2, and to a lesser extent by insulin. The IGF-1R is structurally similar to the insulin receptor and consists of two extracellular α-subunits involved in ligand binding and two transmembrane β-subunits containing a tyrosine kinase domain. Upon activation, IGF-1R triggers several intracellular signaling pathways, including the PI3K/Akt/mTOR and RAS/RAF/MAPK pathways, which promote cell survival, inhibit apoptosis, and regulate metabolism. Additionally, IGF-1R has been found to migrate to the cell nucleus, where it can act as a transcriptional activator. Given its significant anti-apoptotic and pro-survival functions, IGF-1R is highly expressed in many types of cancer and is considered a promising target for cancer therapy.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 25741187176

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.5 ★★★★★
Based on 21 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
D
Verified Purchase
DDT
Port Orchard, US
★★★★★ 5
Great fun for our dogs!
Style: Original
My dogs can’t get enough of this very noisy ball. We have one outside and one in their playroom. It is very noisy. It is very hard. So, I’d say a room with fine furniture is not the place for it. Ours bang it around pretty good. Our boxer did split one, biting it. But, she’s a serious chewer! Our other dog carries it around sometimes but hasn’t been able to damage it yet. So, I’d say for most chewers it’s going to last a long time. It’s a great toy but in most households I’d say basement or outside. Again, it’s hard and did ding a few baseboards.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 27, 2026
L
Verified Purchase
Luna Cherry
Omaha, US
★★★★★ 5
Superb!
Style: Original
My dog absolutely loves this ball. It's too big for him to fit all the way in his mouth, so it's held up pretty well and still makes the sounds.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 31, 2026
M
Verified Purchase
Matthew
Dallas, US
★★★★★ 4
Fun, but buy a couple of them
Style: Original, Style: Original
She loves them. Great toy, but the product can’t hold up- purchased 4-11-2026
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 15, 2026
K
Verified Purchase
Kay Cee
Charlottesville, US
★★★★★ 5
Durable, Rugged, Dog Approved Fun!!
Style: Original, Style: Original
This thing is durable and worth every penny! I bought this over 5 years ago for my rescue and he STILL loves it. He plays with it near daily and it's got a LOT of love-work scrapes, scratches, and scuffs. But it still works perfectly!! Because he's on the medium side, he can't quite bite down on it. Not sure how it'd hold up to heavy chewers with larger mouths. But he can play with this solo for ages and has SO MUCH fun. We love to listen to his "conversations" as he gets into it with this ball. It's been a winner since the day we took it out of the box. It's also the longest lasting toy we still have! Everything else either wore out, was destroyed, or broke. This battery-free ball has made the cut for us.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 2, 2026
S
Verified Purchase
Stephanie
Louisville, US
★★★★★ 3
Lasted a day for my dog
Style: Original, Style: Original
My dog absolutely loved this toy, but sadly it didn’t even last a full day 😩 I’m not sure if that’s because I have a Rottweiler/Lab mix with the jaw strength of a tiny excavator, or if the durability just isn’t great. Within a few hours, he had already torn right through it 🥲 That said, the sound it makes had us cracking up and definitely kept my dog entertained and intrigued while it lasted!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 27, 2026

recommand products