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Description
CCL14a/HCC-1(66aa) Protein, HumanProduct Specification Species Human Synonyms C C motif chemokine 14; Chemokine CC 1 CC 3 (HCC 1 HCC 3); HCC 1(1 74); NCC 2; Small inducible cytokine A14; Accession Q16627 Amino Acid Sequence Gly28 Asn93 Expression System E. coli Molecular Weight 7. 8 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM PB, 500mM NaCl, pH7. 0 Reconstitution
Product Specification
| Species | Human |
| Synonyms | C-C motif chemokine 14; Chemokine CC-1/CC-3 (HCC-1/HCC-3); HCC-1(1-74); NCC-2; Small-inducible cytokine A14; |
| Accession | Q16627 |
| Amino Acid Sequence | Gly28-Asn93 |
| Expression System | E.coli |
| Molecular Weight | 7.8 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM PB, 500mM NaCl, pH7.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | BMC Genomics. 2008 May 15:9:222. |
Background
CCL14a, also known as HCC-1 (Hematopoietic Cell-Derived CC Chemokine 1), is a chemokine belonging to the CC chemokine family. It is involved in immune regulation and inflammation. CCL14a/HCC-1 is produced by various cell types, including monocytes, macrophages, and dendritic cells, in response to inflammatory stimuli.
CCL14a/HCC-1 functions by binding to specific chemokine receptors on target cells, such as CCR1 and CCR5, to induce chemotaxis and activation of immune cells. It plays a role in recruiting leukocytes to sites of inflammation and modulating immune responses.
Research has shown that CCL14a/HCC-1 is implicated in various physiological and pathological processes, including immune cell trafficking, inflammatory diseases, and cancer. Understanding the role of CCL14a/HCC-1 in these processes may provide insights into potential therapeutic strategies for targeting this chemokine in the treatment of related conditions.
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