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Description
ICOS/CD278(C136S, C137S) His Tag Protein, HumanProduct Specification Species Human Synonyms AILIM, CVID1, inducible T cell co stimulator, inducible T cell costimulatory Accession Q9Y6W8 1 Amino Acid Sequence Glu21 Phe141C136S,C137Swith His Tag at the C Terminus Expression System HEK293 Molecular Weight 25 33kDa (Reducing) Purity 95% by SDS PAGE & HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at
Product Specification
| Species | Human |
| Synonyms | AILIM, CVID1, inducible T-cell co-stimulator, inducible T-cell costimulatory |
| Accession | Q9Y6W8-1 |
| Amino Acid Sequence | Glu21-Phe141（C136S,C137S）with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 25-33kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Beier KC, Hutloff A, Dittrich AM, Heuck C, Rauch A, Büchner K, Ludewig B, Ochs HD, Mages HW, Kroczek RA. Induction, binding specificity and function of human ICOS. Eur J Immunol. 2000 Dec;30(12):3707-17. |
Background
ICOS (The inducible T cell co-stimulator) belongs to the CD28 family of co-stimulatory molecules, and it is selectively expressed by activated T-cells, while its ligand is constitutively present on the surface of a variety of cells including dendritic cells, macrophages, B-cells but also on endothelial cells, lung epithelial cells and fibroblasts. ICOS has been implicated in various immune outcomes, including the induction and regulation of Th1, Th2, and Th17 immunity. The triggering of ICOS on T-cells by ICOSL has been shown to modulate lymphocyte cytokine secretion pattern and, in some conditions, to favour regulatory T- cell (Treg) differentiation. In addition to its role in directing effector T cell differentiation, ICOS has also been consistently linked with the induction of thymus-dependent (TD) antibody (Ab) responses and the germinal center (GC) reaction. The initiation of the ICOS pathway begins through ligation of ICOS and its ligand (ICOSL), which is expressed on B cells, macrophages, and dendritic cells. Ligation triggers a downstream pathway that regulates T-cell proliferation and survival, as well as secretion of IL4, IL10, and IFN. OX40 and ICOS cooperate in a nonredundant manner to maximize and sustain Th cell immune responses. In addition, ICOS/ICOSL Interaction plays an important role in the development and differentiation of Follicular T-helper cells (Tfh) in the germinal centres of lymphatic nodes.
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