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Description
Armenian hamster Anti-Human/Mouse/Rat CD278 Antibody (S-R578)Product Specification Host Armenian hamster Antigen CD278 Synonyms Inducible T cell costimulator; Activation inducible lymphocyte immunomediatory molecule; AILIM; ICOS Location Cell membrane Accession Q9Y6W8 Clone Number S R578 Antibody Type Recombinant mAb Isotype IgG Application FCM Reactivity Hu, Ms, Rt Positive Sample Human PBMC Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7.
Product Specification
| Host | Armenian hamster |
| Antigen | CD278 |
| Synonyms | Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; AILIM; ICOS |
| Location | Cell membrane |
| Accession | Q9Y6W8 |
| Clone Number | S-R578 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:2000 | Hu |
Background
CD278, also known as ICOS (inducible T-cell costimulator), is a costimulatory receptor belonging to the CD28 family, mainly expressed on activated CD4 and CD8 T cells, and weakly expressed on naïve T cells. It is a type-1 transmembrane molecule with a single Ig V-like domain, a transmembrane region of 23 amino acids, and a cytoplasmic domain of 35 amino acids. Structurally, it is similar to CD28 and CTLA-4 but lacks the MYPPPY motif found in CD28, which is critical for binding to B7-1 and B7-2. ICOS plays a crucial role in T cell activation and differentiation, particularly in the development and maintenance of T follicular helper (Tfh) cells. It is also involved in the regulation of cytokine production and cell motility, promoting the migration of T cells to the follicle. Additionally, ICOS signaling can induce the expression of CXCR5 and Bcl6, and suppress the expression of CCR7, PSGL-1, and CD62L through the factor KLF2.
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Exchange/Return Notes
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