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Description
APC Armenian hamster Anti-Mouse/Rat CD61 Antibody (S-R656)Product Specification Host Armenian hamster Antigen CD61 Synonyms Integrin beta 3; Platelet membrane glycoprotein IIIa (GPIIIa); Itgb3 Location Cell membrane, Synapse Accession O54890 Clone Number S R656 Antibody Type Recombinant mAb Isotype IgG Application FCM Reactivity Ms, Rt Positive Sample C57BL 6 mouse bone marrow Purification Protein G Concentration 0. 2 mg ml Conjugation APC Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin
Product Specification
| Host | Armenian hamster |
| Antigen | CD61 |
| Synonyms | Integrin beta-3; Platelet membrane glycoprotein IIIa (GPIIIa); Itgb3 |
| Location | Cell membrane, Synapse |
| Accession | O54890 |
| Clone Number | S-R656 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Ms, Rt |
| Positive Sample | C57BL/6 mouse bone marrow |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms, Rt |
Background
CD61, also known as integrin β3, is a 90-92 kDa type I transmembrane glycoprotein that dimerizes with integrin αIIb (CD41) to form the platelet fibrinogen receptor GPIIb/IIIa or with integrin αV (CD51) to form the vitronectin receptor, and plays a pivotal role in platelet aggregation, clot retraction, angiogenesis, and the adhesion and migration of osteoclasts, smooth muscle cells and tumor cells via recognition of RGD motifs in ligands such as fibrinogen, fibronectin, von Willebrand factor, vitronectin and thrombospondin.
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